Document Detail

Cryotherapy for retinopathy of prematurity: a MRI study of the surgical-anatomical relationship of the neonatal conjunctival fornices to the globe.
MedLine Citation:
PMID:  11702967     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To demonstrate the surgical-anatomical relationship of the neonatal conjunctival fornices to the globe in order to ascertain whether adequate cryotherapy is possible in infants with stage 3 retinopathy of prematurity using a trans-scleral approach without opening the conjunctiva. METHODS: Magnetic resonance (MR) scans of the orbit were performed on an adult and an infant of 38 weeks post-conceptual age with maximal posterior placement of a MR-compatible replica of the Schulenburg cryoprobe in the nasal and temporal aspects of the globe. RESULTS: In the infant MR scan, the scleral indentation produced by the probe was anterior to the equator on the nasal side and at, or just anterior to, the equator on the temporal side. Nasally, the scleral indentation reached only the more anterior part and not the posterior part of zone 2 and none of zone 1. Temporally, the scleral indentation reached the central part of zone 2 but not the posterior part of zone 2 or zone 1. CONCLUSION: The findings suggest that adequate cryotherapy with a trans-scleral approach without opening the conjunctiva is unlikely to be achieved in the more immature neonate with posteriorly located retinopathy of prematurity. To permit access of the cryoprobe to the more posterior part of the globe, one radial conjunctival incision from the corneal limbus in each quadrant may be required to achieve adequate ablation of the posterior non-vascularised retina in these high-risk infants.
W E Schulenburg; Y F Yang; E Parikakis; G M Bydder
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Eye (London, England)     Volume:  15     ISSN:  0950-222X     ISO Abbreviation:  Eye (Lond)     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-11-12     Completed Date:  2001-12-11     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  8703986     Medline TA:  Eye (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  587-90     Citation Subset:  IM    
Western Eye Hospital, London, UK.
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MeSH Terms
Conjunctiva / anatomy & histology*
Cryotherapy / methods*
Feasibility Studies
Infant, Newborn
Linear Models
Magnetic Resonance Imaging / methods
Orbit / anatomy & histology*
Retinopathy of Prematurity / diagnosis,  therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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