| Cryosurgery and topical fluorouracil: a treatment method for widespread basal cell epithelioma in basal cell nevus syndrome. | |
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MedLine Citation:
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PMID: 8245314 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 58-year-old man with basal cell nevus syndrome had variously sized basal cell epitheliomas (BCEs), mostly of the superficial type, on his chest, back, and lumbar areas. BCEs on the lumbar area were treated with 5-fluorouracil (5-FU) cream which was applied daily under occlusive dressings (ODT). Complete erosion occurred in the center, but not at the periphery of the lesions. In the latter regions, BCE remained. Then cryosurgery (cryo) followed by topical 5-FU (cryo + 5-FU) was tried to treat the peripheral, non-eroded lesions; this caused complete erosions. Biopsy specimens obtained 6 months after epithelization did not show any evidence of recurrence. We also tried either cryo alone or cryo + 5-FU on the chest lesions, and either 5-FU alone or cryo + 5-FU on the abdominal lesions. Cryo alone or 5-FU alone could not clear BCE, but cryo + 5-FU could. These results suggest that the cryo + 5-FU was the most effective of these therapies. |
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Authors:
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T Tsuji; N Otake; M Nishimura |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of dermatology Volume: 20 ISSN: 0385-2407 ISO Abbreviation: J. Dermatol. Publication Date: 1993 Aug |
Date Detail:
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Created Date: 1994-01-06 Completed Date: 1994-01-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7600545 Medline TA: J Dermatol Country: JAPAN |
Other Details:
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Languages: eng Pagination: 507-13 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Nagoya City University Medical School, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Back Basal Cell Nevus Syndrome / pathology, therapy* Carcinoma, Basal Cell / pathology, therapy* Combined Modality Therapy Cryosurgery* Fluorouracil / administration & dosage* Humans Male Middle Aged Neoplasms, Multiple Primary* Occlusive Dressings Skin / pathology Skin Neoplasms / pathology, therapy* Thorax |
| Chemical | |
Reg. No./Substance:
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51-21-8/Fluorouracil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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