Document Detail

Cryopreserved vein transplantation.
MedLine Citation:
PMID:  1606369     Owner:  NLM     Status:  MEDLINE    
There have been numerous attempts to develop prosthetic conduits or utilize allograft saphenous veins for arterial bypass. This article summarizes our experimental and clinical experience with cryopreserved allograft saphenous veins. During these studies, particular attention was paid to vein donor postmortem ischemia time, vein procurement technique, and tissue storage methods. Experimental cryopreserved autograft studies demonstrated that cryopreservation of the veins does not alter subsequent graft patency, the arterialization process, blood flow, or platelet deposition in vein grafts. Endothelium-derived relaxing and contractile factors are produced by the endothelium of explanted cryopreserved autografts, and smooth muscle contractions and relaxations can be induced. In experimental cryopreserved allografts, the endothelium appears to be removed by an immune response during the first 10 days after transplantation, fibrin deposition is minimal, and re-endothelialization occurs over 6-9 months. Early clinical results using cryopreserved allograft saphenous veins are encouraging with 1-year patency rates of 79% for peripheral grafts and 86% for coronary bypass grafts.
K G Brockbank; R T McNally; K A Walsh
Related Documents :
1418759 - Anatomical observation on draining patterns of saphenous tributaries in korean adults.
9420119 - A quicker saphenous vein cutdown and a better way to teach it.
6965329 - Severe adhesive constrictive pericarditis after coronary artery bypass.
2745539 - Short segments of frozen saphenous allografts for construction of a-v fistula.
16336429 - Distal embolic protection for svg interventions: can we afford not to use it?
20831999 - Covered stent treatment for an aneurysm of a saphenous vein graft to the common carotid...
21417839 - Minimally invasive repair of the mitral valve: technological and clinical developments.
3522199 - Procedures for respiratory function.
15091109 - Endothelial nitric oxide synthase gene polymorphisms predict susceptibility to aneurysm...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiac surgery     Volume:  7     ISSN:  0886-0440     ISO Abbreviation:  J Card Surg     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-07-23     Completed Date:  1992-07-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8908809     Medline TA:  J Card Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  170-6     Citation Subset:  IM    
CryoLife, Inc., Marietta, Georgia 30067.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Clinical Protocols / standards
Clinical Trials as Topic
Cryopreservation / methods,  standards*
Endothelium, Vascular / immunology,  pathology
Evaluation Studies as Topic
Graft Survival
Middle Aged
Muscle Contraction
Platelet Adhesiveness
Saphenous Vein / transplantation*
Survival Analysis
Time Factors
Tissue Donors
Transplantation, Homologous / methods*
Vascular Patency

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Experimental evaluation of the dialdehyde starch preserved bovine internal mammary artery as a small...
Next Document:  Molecular approaches to the characterization of cell and blood/biomaterial interactions.