Document Detail


Cryopreserved vein transplantation.
MedLine Citation:
PMID:  1606369     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There have been numerous attempts to develop prosthetic conduits or utilize allograft saphenous veins for arterial bypass. This article summarizes our experimental and clinical experience with cryopreserved allograft saphenous veins. During these studies, particular attention was paid to vein donor postmortem ischemia time, vein procurement technique, and tissue storage methods. Experimental cryopreserved autograft studies demonstrated that cryopreservation of the veins does not alter subsequent graft patency, the arterialization process, blood flow, or platelet deposition in vein grafts. Endothelium-derived relaxing and contractile factors are produced by the endothelium of explanted cryopreserved autografts, and smooth muscle contractions and relaxations can be induced. In experimental cryopreserved allografts, the endothelium appears to be removed by an immune response during the first 10 days after transplantation, fibrin deposition is minimal, and re-endothelialization occurs over 6-9 months. Early clinical results using cryopreserved allograft saphenous veins are encouraging with 1-year patency rates of 79% for peripheral grafts and 86% for coronary bypass grafts.
Authors:
K G Brockbank; R T McNally; K A Walsh
Related Documents :
1286999 - Venous homografts in infra-inguinal procedures: an eight years experience.
15838269 - Surgical trauma and vein graft failure: further evidence for a role of et-1 in graft oc...
10559819 - Successful treatment of a saphenous vein graft perforation with an autologous vein-cove...
6446269 - Below-knee bypass for limb salvage. comparison of autogenous saphenous vein, polytetraf...
2745539 - Short segments of frozen saphenous allografts for construction of a-v fistula.
6501399 - The advantage of the thoraco-retroperitoneal approach for aortorenal bypass grafting.
3518249 - Topographic aspects of prostacyclin-like and fibrinolytic activity and of biogenic amin...
10378829 - Trousseau's syndrome with brachiocephalic vein thrombosis in a patient with uterine car...
25444569 - The link between ventricular repolarization variables and arterial function.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiac surgery     Volume:  7     ISSN:  0886-0440     ISO Abbreviation:  J Card Surg     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-07-23     Completed Date:  1992-07-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8908809     Medline TA:  J Card Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  170-6     Citation Subset:  IM    
Affiliation:
CryoLife, Inc., Marietta, Georgia 30067.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Animals
Clinical Protocols / standards
Clinical Trials as Topic
Cryopreservation / methods,  standards*
Dogs
Endothelium, Vascular / immunology,  pathology
Evaluation Studies as Topic
Female
Graft Survival
Humans
Male
Middle Aged
Muscle Contraction
Platelet Adhesiveness
Saphenous Vein / transplantation*
Survival Analysis
Time Factors
Tissue Donors
Transplantation, Homologous / methods*
Vascular Patency

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Experimental evaluation of the dialdehyde starch preserved bovine internal mammary artery as a small...
Next Document:  Molecular approaches to the characterization of cell and blood/biomaterial interactions.