Document Detail


Cryoplasty for the prevention of arterial restenosis.
MedLine Citation:
PMID:  18535858     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Restenosis after percutaneous transluminal angioplasty remains the limiting factor for the long-term benefit of endovascular therapies of peripheral arterial occlusive disease. Despite a variety of modifications and adjuncts to angioplasty such as bare metal stents, covered stents, and drug-eluting stents as well as a number of new technologies like laser angioplasty and cutting balloon angioplasty, restenosis rates have not been significantly affected and remain inferior to those for surgery for long lesions in the femoropopliteal segment. Cryoplasty, which combines balloon angioplasty with the application of cryothermal energy to the vessel wall, was suggested as a promising approach to prevent the formation of neointimal hyperplasia after angioplasty procedures. This review discusses the basic principles of cryoplasty, summarizes the current data on restenosis rates after cryoplasty treatment, and evaluates cryoplasty as a new treatment method to solve the problems associated with restenosis development. The results of the clinical studies suggest that cryoplasty is a feasible and safe technique in the treatment of femoropopliteal disease, however, they have failed to prove any superiority of cryoplasty over conventional angioplasty.
Authors:
Moritz G Wildgruber; Hermann J Berger
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-06-06
Journal Detail:
Title:  Cardiovascular and interventional radiology     Volume:  31     ISSN:  1432-086X     ISO Abbreviation:  Cardiovasc Intervent Radiol     Publication Date:    2008 Nov-Dec
Date Detail:
Created Date:  2008-11-07     Completed Date:  2009-03-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003538     Medline TA:  Cardiovasc Intervent Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1050-8     Citation Subset:  IM    
Affiliation:
Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 13th Street, Building 149, Charlestown, MA 02129, USA. wildgruber.moritz@mgh.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Angioplasty / methods
Animals
Apoptosis
Arterial Occlusive Diseases / prevention & control*,  therapy
Cryotherapy / methods*
Graft Occlusion, Vascular / prevention & control*
Humans
Hyperplasia
Peripheral Vascular Diseases / prevention & control*,  therapy
Recurrence / prevention & control
Tunica Intima / pathology
Vascular Patency / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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