| Cryoplasty for femoropopliteal arterial disease: late angiographic results of initial human experience. | |
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MedLine Citation:
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PMID: 15525742 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: A new form of angioplasty, called cryoplasty, was developed to improve the late results typically associated with percutaneous transluminal angioplasty. Cryoplasty combines the dilation force of percutaneous transluminal angioplasty with the delivery of cold thermal energy to the vessel wall. This study reports the authors' early clinical experience with cryoplasty in patients with femoropopliteal disease. MATERIALS AND METHODS: Fifteen patients with femoropopliteal arterial lesions were treated with cryoplasty (CryoVascular Systems, Los Gatos, CA). Cryoplasty was performed at 6 atm of pressure and delivered at -10 degrees C for 60 seconds. The ankle-brachial index (ABI) was measured at baseline, 24 hours after cryoplasty, and at 1 and 3 months during follow-up. Repeated angiography was performed at 6 and 18 months to determine short-term and late primary patency. RESULTS: Cryoplasty was technically successful in 93% of patients (< 30% residual stenosis and less then grade C dissection). ABIs at baseline were 0.64 +/- 0.08 and improved the day after cryoplasty to 0.95 +/- 0.09 (P < .05). ABIs were well maintained at 1 and 3 months with measurements of 0.94 +/- 0.09 and 0.92 +/- 0.10, respectively (P < .05 vs baseline). Baseline angiographic diameter stenosis improved significantly immediately following cryoplasty (86% +/- 12% to 16% +/- 3%; P < .05). Angiography at 6 months revealed 0% binary restenosis and insignificant change in residual stenosis from the acute cryoplasty results (16 +/- 3% vs 21 +/- 5%; P = NS). Late angiographic follow-up at 14 months +/- 4 demonstrated primary patency of 83.3%. CONCLUSION: Cryoplasty was able to achieve substantial dilation of femoropopliteal lesions with well-preserved late angiographic patency. Cryoplasty represents a potential advance in the field of endovascular medicine. |
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Authors:
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Mario Fava; Soledad Loyola; Antonios Polydorou; Prodromos Papapavlou; Adamandia Polydorou; Oscar Mendiz; James D Joye |
Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Journal of vascular and interventional radiology : JVIR Volume: 15 ISSN: 1051-0443 ISO Abbreviation: J Vasc Interv Radiol Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-11-04 Completed Date: 2005-03-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9203369 Medline TA: J Vasc Interv Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 1239-43 Citation Subset: IM |
Affiliation:
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Universidad Catolica, Santiago, Chile. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Analysis of Variance Angioplasty, Balloon / instrumentation*, methods, statistics & numerical data Arterial Occlusive Diseases / radiography, therapy* Constriction, Pathologic / radiography, therapy Cross-Sectional Studies Cryotherapy / instrumentation*, methods Equipment Design / methods Female Femoral Artery / radiography* Follow-Up Studies Humans Leg / blood supply, radiography Male Popliteal Artery / radiography* Time Factors Treatment Outcome Vascular Patency / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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