| Cryoglobulinemia vasculitis: an update. | |
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MedLine Citation:
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PMID: 23196322 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Cryoglobulinemia vasculitis (CryoVas) is a small-vessel vasculitis associated with chronic infections [in particular hepatitis C virus, (HCV)], autoimmune disorders and B-cell lymphoproliferative disorders. The most recent studies on its diagnosis, prognosis and therapeutic management are reviewed here. RECENT FINDINGS: Large series of patients with HCV-positive and negative mixed CryoVas and patients with monoclonal type I CryoVas have described the presentation and the prognosis of patients with CryoVas in the era of HCV screening. European experts in the field of CryoVas developed new classification criteria for its diagnosis. Finally, French, Italian and North American clinical studies demonstrated that rituximab-based regimens were highly effective in comparison with corticosteroids alone or other immunosuppressive agents-based therapy. However, rituximab seems to be associated with an increased risk of severe infections in a subset of patients. SUMMARY: Recent studies identified prognostic factors of survival and demonstrated that rituximab is highly effective but remains associated with severe infections in a subset of patients. These results could support individual therapeutic stratification according to the clinical pattern and associated comorbidities. |
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Authors:
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Benjamin Terrier; Patrice Cacoub |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current opinion in rheumatology Volume: 25 ISSN: 1531-6963 ISO Abbreviation: Curr Opin Rheumatol Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2012-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9000851 Medline TA: Curr Opin Rheumatol Country: United States |
Other Details:
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Languages: eng Pagination: 10-8 Citation Subset: IM |
Affiliation:
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aUPMC Univ Paris 06, UMR 7211, F-75005, Paris, France bINSERM, UMR_S 959, F-75013, Paris, France cCNRS, UMR 7211, F-75005, Paris, France dAP-HP, Groupe Hospitalier Pitié-Salpêtrière, Paris, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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