Document Detail

Cryoablation vs radiofrequency ablation for the treatment of renal cell carcinoma: a meta-analysis of case series studies.
MedLine Citation:
PMID:  22304329     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: • To determine the current status of the literature regarding the clinical efficacy and complication rates of cryoablation vs radiofrequency ablation in the treatment of small renal tumours.
METHODS: • A review of the literature was conducted. There was no language restriction. Studies were obtained from the following sources: MEDLINE, EMBASE and LILACS. • Inclusion criteria were (i) case series design with more than one case reported, (ii) use of cryoablation or radiofrequency ablation, (iii) patients with renal cell carcinoma and, (iv) outcome reported as clinical efficacy. • When available, we also quantified the complication rates from each included study. • Proportional meta-analysis was performed on both outcomes with a random-effects model. The 95% confidential intervals were also calculated.
RESULTS: • Thirty-one case series (20 cryoablation, 11 radiofrequency ablation) met all inclusion criteria. • The pooled proportion of clinical efficacy was 89% in cryoablation therapy from a total of 457 cases. There was a statistically significant heterogeneity between these studies showing the inconsistency of clinical and methodological aspects. • The pooled proportion of clinical efficacy was 90% in radiofrequency ablation therapy from a total of 426 cases. There was no statistically significant heterogeneity between these studies. • There was no statistically significant difference regarding complications rate between cryoablation and radiofrequency ablation.
CONCLUSIONS: • This review shows that both ablation therapies have similar efficacy and complication rates. • There is urgency for performing clinical trials with long-term data to establish which intervention is most suitable for the treatment of small renal masses.
Regina El Dib; Naji J Touma; Anil Kapoor
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Publication Detail:
Type:  Comparative Study; Journal Article; Meta-Analysis; Review     Date:  2012-02-03
Journal Detail:
Title:  BJU international     Volume:  110     ISSN:  1464-410X     ISO Abbreviation:  BJU Int.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-27     Completed Date:  2012-10-09     Revised Date:  2013-01-29    
Medline Journal Info:
Nlm Unique ID:  100886721     Medline TA:  BJU Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  510-6     Citation Subset:  IM    
Copyright Information:
Botucatu School of Medicine, UNESP - Univ Estadual Paulista, Botucatu, Brazil.
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MeSH Terms
Analgesics / therapeutic use
Carcinoma, Renal Cell / surgery*
Catheter Ablation / methods*
Cryosurgery / methods*
Kidney Neoplasms / surgery*
Laparoscopy / statistics & numerical data
Length of Stay
Middle Aged
Pain, Postoperative / prevention & control
Recovery of Function
Treatment Outcome
Reg. No./Substance:
Comment In:
J Urol. 2013 Jan;189(1):70   [PMID:  23235207 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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