| Cryo-ultramicrotomy as a tool for the assessment of doxorubicine cardiotoxicity in rats. | |
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MedLine Citation:
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PMID: 7389974 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cryo-ultramicrotomy was tested as a tool for the assessment of cardiac damage induced by doxorubicine in rats. Slightly fixed specimens were cut at -80 or -90 degrees C (knife temperature -60 or -70 degrees C), and the ultrastructural changes observed were compared with those found in conventional epoxy sections. It is concluded that the cryo method, although using more elaborate equipment and being more painstaking, might yield more sensitive parameters for cardiac damage than epoxy sections. |
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Authors:
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C Holderegger; G Zbinden |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Experimental cell biology Volume: 48 ISSN: 0304-3568 ISO Abbreviation: Exp. Cell Biol. Publication Date: 1980 |
Date Detail:
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Created Date: 1980-09-28 Completed Date: 1980-09-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7701827 Medline TA: Exp Cell Biol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 349-55 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Doxorubicin / toxicity* Drug Evaluation, Preclinical / methods Epoxy Resins Female Frozen Sections Heart / drug effects* Microscopy, Electron Microtomy / methods* Mitochondria, Heart / ultrastructure Myocardium / ultrastructure Rats |
| Chemical | |
Reg. No./Substance:
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0/Epoxy Resins; 23214-92-8/Doxorubicin; 67076-53-3/EPON |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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