Document Detail

Crumbs homologue 1 in polarity and blindness.
MedLine Citation:
PMID:  15494026     Owner:  NLM     Status:  MEDLINE    
Several retinal dystrophies, including retinitis pigmentosa type 12 and Leber congenital amaurosis, are caused by a large variety of mutations in the CRB1 (Crumbs homologue 1) gene. This discovery led to an increased focus on the function of CRB1 and the Drosophila homologue Crumbs. In the present study, we review the current knowledge on Crumbs and its vertebrate homologues, their function in cell polarity and their pathogenicity in retinal degeneration.
J Meuleman; S A van de Pavert; J Wijnholds
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Biochemical Society transactions     Volume:  32     ISSN:  0300-5127     ISO Abbreviation:  Biochem. Soc. Trans.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-20     Completed Date:  2005-04-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7506897     Medline TA:  Biochem Soc Trans     Country:  England    
Other Details:
Languages:  eng     Pagination:  828-30     Citation Subset:  IM    
The Netherlands Ophthalmic Research Institute, Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105 BA Amsterdam, The Netherlands.
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MeSH Terms
Amino Acid Sequence
Drosophila Proteins / metabolism,  physiology*
Eye Proteins / metabolism,  physiology*
Membrane Proteins / metabolism,  physiology*
Models, Biological
Molecular Sequence Data
Nerve Tissue Proteins / metabolism,  physiology*
Protein Structure, Tertiary
Retinal Degeneration / genetics*
Sequence Homology, Amino Acid
Reg. No./Substance:
0/CRB1 protein, human; 0/Drosophila Proteins; 0/Eye Proteins; 0/Membrane Proteins; 0/Nerve Tissue Proteins; 0/crumbs protein, Drosophila

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