Document Detail

Crucial role of renin-angiotensin system in the pathogenesis of atherosclerosis.
MedLine Citation:
PMID:  20299739     Owner:  NLM     Status:  MEDLINE    
The renin-angiotensin system (RAS) has been demonstrated to play a critical role in the initiation and progression of atherosclerosis, thereby contributing to development of cardiovascular diseases. Angiotensin II (Ang II), a major substrate in RAS, stimulates atherosclerosis through various deleterious effects such as endothelial dysfunction, cellular proliferation and inflammation. Recently, local RAS in vasculature is reported to play an important role. Many of these atherogenic actions of Ang II are mediated by reactive oxygen species (ROS). Investigation of the role of ROS and inflammation induced by RAS may provide a clue to understanding the pathophysiology of atherosclerotic diseases, and may lead to a new therapeutic strategy.
Masataka Sata; Daiju Fukuda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The journal of medical investigation : JMI     Volume:  57     ISSN:  1349-6867     ISO Abbreviation:  J. Med. Invest.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-19     Completed Date:  2010-06-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9716841     Medline TA:  J Med Invest     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  12-25     Citation Subset:  IM    
Department of Cardiovascular Medicine, Institute of Health Bioscience, University of Tokushima Graduate School, Tokushima, Japan.
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MeSH Terms
Angiotensin II / pharmacology
Atherosclerosis / etiology*
Bone Marrow / physiology
Reactive Oxygen Species / metabolism
Receptor, Angiotensin, Type 1 / physiology
Receptor, Angiotensin, Type 2 / physiology
Renin-Angiotensin System / physiology*
Reg. No./Substance:
0/Reactive Oxygen Species; 0/Receptor, Angiotensin, Type 1; 0/Receptor, Angiotensin, Type 2; 11128-99-7/Angiotensin II

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