| Crucial dietary factors in maximizing life span and longevity in autoimmune-prone mice. | |
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MedLine Citation:
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PMID: 3598724 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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When the energy intake of (NZB X NZW)F1 female mice was reduced to 60% of the intake of simultaneously ad libitum-fed mice, the early death associated with autoimmune-based renal disease in this strain was greatly delayed. The length of prolongation of disease-free life depended not only on the decreased energy intake but also on the energy source. In the group of mice with 60% intake of a carbohydrate-free (i.e., high fat) diet, mean longevity was doubled as compared to that of ad libitum-fed mice. However, when the nonprotein energy was supplied by carbohydrate (sucrose and glycerol) the mean longevity was three times that of the ad libitum-fed groups, although survival times varied widely. With ad libitum feeding the nonprotein energy source did not significantly affect longevity. Clearly, although energy intake restriction provides significant influence on longevity, very high fat diets do not give the same protection as do high carbohydrate diets. The basis for this difference is not entirely clear and several explanations are possible. |
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Authors:
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C Kubo; B C Johnson; A Gajjar; R A Good |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of nutrition Volume: 117 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 1987 Jun |
Date Detail:
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Created Date: 1987-08-07 Completed Date: 1987-08-07 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1129-35 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigen-Antibody Complex / analysis Autoantibodies / analysis Autoimmune Diseases / immunology, prevention & control* Body Weight DNA / immunology Diet* Dietary Carbohydrates / administration & dosage Dietary Fats / administration & dosage* Energy Intake* Female Kidney Diseases / immunology*, prevention & control Longevity* Mice Mice, Inbred NZB Proteinuria / immunology |
| Grant Support | |
ID/Acronym/Agency:
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AGO5628/AG/NIA NIH HHS; AGO5633/AG/NIA NIH HHS; AI22360/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigen-Antibody Complex; 0/Autoantibodies; 0/Dietary Carbohydrates; 0/Dietary Fats; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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