Document Detail


Crotalic and emarginellic acids: two triterpenes from Crotalaria emarginella and anti-inflammatory and anti-hepatotoxic activity of crotalic acid.
MedLine Citation:
PMID:  16624352     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aerial parts of Crotalaria emarginella Vatke (Leguminosae) has afforded two triterpenes, characterized as 3alpha-hydroxy-arbor-12-ene-28-carboxylic acid, designated as crotalic acid (1), and 2beta,3beta,21-trihydroxy-arbor-12-ene-29-carboxylic acid, designated as emarginellic acid (2). The structures of the isolated products were elucidated on the basis of spectral and chemical studies. On screening the biological activity, the crotalic acid (1) exhibited a significant anti-inflammatory activity (dose: 10mg/kg), which showed 53% inhibitory effect. Whereas, the standard oxyphenyl butazone (100mg/kg) exhibited 69% inhibition with respect to carrageenan (0.05ml, 1%) used to cause inflammation in rat paw method. In addition, it also showed anti-hepatotoxic activity by 13-30% with respect to standard silybon-70 (35-57%) against CCl(4) induced toxicity in Wistar rats.
Authors:
Bahar Ahmed; Tawfeq A Al-Howiriny; Jaber S Mossa
Publication Detail:
Type:  Journal Article     Date:  2006-04-18
Journal Detail:
Title:  Phytochemistry     Volume:  67     ISSN:  0031-9422     ISO Abbreviation:  Phytochemistry     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-29     Completed Date:  2006-08-31     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0151434     Medline TA:  Phytochemistry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  956-64     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Chemistry, F/O Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi 110062, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents / chemistry*,  pharmacology*
Carbon Tetrachloride
Crotalaria / chemistry*
Drug-Induced Liver Injury
Edema / drug therapy
Liver Diseases / prevention & control*
Molecular Conformation
Protective Agents / pharmacology
Rats
Triterpenes / chemistry*,  isolation & purification,  pharmacology*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Protective Agents; 0/Triterpenes; 0/crotalic acid; 0/emarginellic acid; 56-23-5/Carbon Tetrachloride

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