Document Detail

Crosstalk between xenobiotics metabolism and circadian clock.
MedLine Citation:
PMID:  17451689     Owner:  NLM     Status:  MEDLINE    
Many aspects of physiology and behavior in organisms from bacteria to man are subjected to circadian regulation. Indeed, the major function of the circadian clock consists in the adaptation of physiology to daily environmental change and the accompanying stresses such as exposition to UV-light and food-contained toxic compounds. In this way, most aspects of xenobiotic detoxification are subjected to circadian regulation. These phenomena are now considered as the molecular basis for the time-dependence of drug toxicities and efficacy. However, there is now evidences that these toxic compounds can, in turn, regulate circadian gene expression and thus influence circadian rhythms. As food seems to be the major regulator of peripheral clock, the possibility that food-contained toxic compounds participate in the entrainment of the clock will be discussed.
Thierry Claudel; Gaspard Cretenet; Anne Saumet; Frédéric Gachon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-04-17
Journal Detail:
Title:  FEBS letters     Volume:  581     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-27     Completed Date:  2007-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  3626-33     Citation Subset:  IM    
Department of Pediatrics, Research Laboratory, University Medical Center Groningen, Groningen, ND-9700 RB, The Netherlands.
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MeSH Terms
Biological Clocks / drug effects,  genetics*
Circadian Rhythm / drug effects,  genetics*
Food / toxicity*
Gene Expression / drug effects
Gene Expression Regulation*
Transcription Factors / metabolism
Xenobiotics / metabolism*,  toxicity
Reg. No./Substance:
0/Transcription Factors; 0/Xenobiotics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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