| Crossover study of amlodipine versus nifedipine CR with home blood pressure monitoring via cellular phone: internet-mediated open-label crossover trial of calcium channel blockers for hypertension (i-TECHO trial). | |
| | |
MedLine Citation:
|
PMID: 17921832 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: We developed a new data collection system named i-converter that could transmit data to a website via cellular phone. Using the system, we compared the effects of two calcium channel blockers on the home blood pressure. METHODS: Amlodipine and nifedipine CR were administered to 41 patients with essential hypertension for more than 6 weeks each in a randomized open-label crossover study. The dose of each drug was increased until the home blood pressure reached the target level of under 135/85 mmHg. RESULTS: The morning home systolic and diastolic blood pressures were significantly lower during nifedipine CR treatment: 133 +/- 10/81 +/- 8 mmHg with amlodipine versus 131 +/- 8/80 +/- 8 mmHg with nifedipine CR, P < 0.05. The morning pulse rate was significantly higher during nifedipine CR treatment (69 +/- 9 beats/min with amlodipine versus 70 +/- 9 beats/min with nifedipine CR, P < 0.05). The evening home blood pressure and pulse rate, however, showed no significant differences between the two drugs (128 +/- 11/74 +/- 7 mmHg and 74 +/- 10 beats/min with amlodipine versus 128 +/- 10/75 +/- 7 mmHg and 74 +/- 9 beats/min with nifedipine CR, all not significant). CONCLUSIONS: Nifedipine CR had a stronger antihypertensive effect than amlodipine during the critical morning period, but the morning pulse rate was higher. Our new data transmission system was effective for collecting precise data on the blood pressure and pulse rate via the internet. |
| | |
Authors:
|
Munekazu Ryuzaki; Hidetomo Nakamoto; Eiichi Nishida; Masayoshi Sone; Sadao Nakajima; Mitsuo Yoshimoto; Yuka Suzuki; Kaori Itagaki |
Publication Detail:
|
Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Journal of hypertension Volume: 25 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 2007 Nov |
Date Detail:
|
Created Date: 2007-10-08 Completed Date: 2008-01-10 Revised Date: 2008-07-03 |
Medline Journal Info:
|
Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
|
Languages: eng Pagination: 2352-8 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Kawasaki Municipal Ida Hospital, Kanagawa, Japan. ryuuzaki-m@city.kawasaki.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Amlodipine / therapeutic use* Blood Pressure Determination* Calcium Channel Blockers / therapeutic use* Cellular Phone* Cross-Over Studies Female Humans Hypertension / drug therapy*, physiopathology Internet* Male Middle Aged Nifedipine / therapeutic use* Pulse Telemedicine* |
| Chemical | |
Reg. No./Substance:
|
0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 88150-42-9/Amlodipine |
| Comments/Corrections | |
Comment In:
|
J Hypertens. 2008 May;26(5):1046-7; discussion 1048
[PMID:
18398351
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Spironolactone has antiarrhythmic activity in ischaemic cardiac patients without cardiac failure.
Next Document: Minimally invasive transiliac plate osteosynthesis for type C injuries of the pelvic ring: a clinica...