Document Detail

Crossover plot study of glycolytic intermediates in the ischemic canine heart.
MedLine Citation:
PMID:  6217359     Owner:  NLM     Status:  MEDLINE    
Effects of regional ischemia on myocardial glycolysis were studied by measuring the levels of glycolytic intermediates in the endo- and epicardial layers of the left ventricle in dogs anesthetized with pentobarbital. Regional ischemia was induced by ligating a small branch of the left anterior descending coronary artery. The myocardial tissue samples were removed before and 1.5, 3, 7, or 30 min after coronary artery ligation. Based on a crossover plot study of the glycolytic intermediates, it is suggested that the activity of glycogen phosphorylase was accelerated, while that of phosphofructokinase was inhibited in ischemic myocardium samples removed 1.5, 3, 7, and 30 min after ligation. When the frozen myocardium was allowed to stand at room temperature for 10 min, the crossover plot study revealed acceleration of phosphofructokinase activity. The metabolic response to regional ischemia of the endocardial layers was more marked than that of the epicardial. During ischemia the levels of adenine nucleotides did not change significantly, but those of citrate and hydrogen ions increased significantly. It appears that inhibition of myocardial phosphofructokinase activity during ischemia is partly due to an increase in the levels of citrate and hydrogen ions in the ischemic tissue.
K Ichihara; Y Abiko
Related Documents :
2962919 - Percutaneous transluminal coronary angioplasty in patients with silent myocardial ische...
2309599 - Exercise-induced silent myocardial ischemia: evaluation by thallium-201 emission comput...
9390589 - Acute hypovolemia may cause segmental wall motion abnormalities in the absence of myoca...
3000159 - Anti-ischemic actions of a new thromboxane receptor antagonist during acute myocardial ...
9356089 - Myocardial ischemia and adverse cardiac outcomes in cardiac patients undergoing noncard...
1543139 - Perspective: the cellular influences of calcium antagonists on systemic and coronary he...
23196659 - Rapid progression of left ventricular thrombus with left ventricular dysfunction detect...
19001019 - Drug-eluting or bare-metal stenting in patients with diabetes mellitus: results from th...
23519269 - Peripartum cardiomyopathy: a contemporary review.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese heart journal     Volume:  23     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1982 Sep 
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  817-28     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenine Nucleotides / metabolism
Coronary Disease / metabolism*
Hydrogen-Ion Concentration
Myocardium / metabolism*
Phosphofructokinase-1 / metabolism
Phosphorylases / metabolism
Reg. No./Substance:
0/Adenine Nucleotides; EC 2.4.1.-/Phosphorylases; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Metabolism of cardiac structural proteins in normal and hypertrophied rabbit heart.
Next Document:  A case of asymmetrical apical hypertrophy which is a form of hypertrophic nonobstructive cardiomyopa...