Document Detail


Crosslinked polyether/polysiloxane networks for blood-interfacing applications.
MedLine Citation:
PMID:  3778997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The interaction of blood with new artificial surfaces is an area of continual medical interest. In this study, a series of polyether/polysiloxane networks were synthesized, characterized in terms of both bulk and surface compositions, and evaluated for blood compatibility. The crosslinked networks were produced by reacting the epoxy groups of polyglycidoxy propyl methyl siloxane (PGPMS) with the hydroxyl end groups of polypropylene glycol (PPG). Blood compatibility was evaluated using an in vitro platelet retention test and fibrinogen adsorption experiments from human plasma and buffered saline. The PPG/PGPMS networks exhibit low fibrinogen adsorption and low platelet activation. Such properties make the networks potentially attractive as materials for blood-interfacing applications.
Authors:
R W Pekala; M Rudoltz; E R Lang; E W Merrill; J Lindon; L Kushner; G McManama; E W Salzman
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biomaterials     Volume:  7     ISSN:  0142-9612     ISO Abbreviation:  Biomaterials     Publication Date:  1986 Sep 
Date Detail:
Created Date:  1986-12-24     Completed Date:  1986-12-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  372-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adsorption
Biocompatible Materials*
Blood*
Blood Platelets / physiology
Fibrinogen
Humans
Polymers*
Propylene Glycols*
Silicones*
Siloxanes*
Surface Properties
Grant Support
ID/Acronym/Agency:
5-RO1-HL20079/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/Polymers; 0/Propylene Glycols; 0/Silicones; 0/Siloxanes; 0/polyglycidoxy propyl methyl siloxane; 25322-69-4/polypropylene glycol; 9001-32-5/Fibrinogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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