| Cross-talk between APC/C and CBP/p300. | |
| | |
MedLine Citation:
|
PMID: 16861917 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
APC/C complex has been known to regulate cell cycle progression via its ubiquitin E3 ligase activity that targets a number of cell cycle regulators. In a recent report, it is shown that APC/C interacts with transcription co-activators, CBP and p300, via its APC5 and APC7 subunits. The authors further demonstrate the functional significance of APC/C-CBP/p300 interaction in regulating both transcription and cell cycle progression. These findings have profound implications in unveiling additional functions and regulatory mechanisms of these two seemingly independent molecular modulators. |
| | |
Authors:
|
Jianghuai Liu; Serge Y Fuchs |
Related Documents
:
|
18759927 - Regulation of b-cell entry into the cell cycle. 16157877 - Statistical methods for identifying yeast cell cycle transcription factors. 11479327 - Analysis of cell division parameters and cell cycle gene expression during the cultivat... 19620627 - Pre-b cell receptor-mediated cell cycle arrest in philadelphia chromosome-positive acut... 17532887 - Color transformation and fluorescence of prussian blue-positive cells: implications for... 12072457 - Ibd2 encodes a novel component of the bub2p-dependent spindle checkpoint in the budding... |
Publication Detail:
|
Type: Journal Article; Review Date: 2006-07-13 |
Journal Detail:
|
Title: Cancer biology & therapy Volume: 5 ISSN: 1538-4047 ISO Abbreviation: Cancer Biol. Ther. Publication Date: 2006 Jul |
Date Detail:
|
Created Date: 2006-08-24 Completed Date: 2006-12-11 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101137842 Medline TA: Cancer Biol Ther Country: United States |
Other Details:
|
Languages: eng Pagination: 760-2 Citation Subset: IM |
Affiliation:
|
Department of Animal Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6046, USA. jiangliu@vet.upenn.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cell Cycle
/
genetics Cell Transformation, Neoplastic / genetics* Cell Transformation, Viral / genetics* Gene Expression Regulation* Humans Transcription, Genetic Ubiquitin-Protein Ligase Complexes / metabolism* p300-CBP Transcription Factors / metabolism* |
| Chemical | |
Reg. No./Substance:
|
EC 2.3.1.48/p300-CBP Transcription Factors; EC 6.3.2.19/Ubiquitin-Protein Ligase Complexes; EC 6.3.2.19/anaphase-promoting complex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Survivin stable knockdown by siRNA inhibits tumor cell growth and angiogenesis in breast and cervica...
Next Document: UPR activation alters chemosensitivity of tumor cells.