| Cross-talk between adipose tissue and vasculature: role of adiponectin. | |
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MedLine Citation:
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PMID: 21062420 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Adipose tissue is a highly dynamic endocrine organ, secreting a number of bioactive substances (adipokines) regulating insulin sensitivity, energy metabolism and vascular homeostasis. Dysfunctional adipose tissue is a key mediator that links obesity with insulin resistance, hypertension and cardiovascular disease. Obese adipose tissue is characterized by adipocyte hypertrophy and infiltration of inflammatory macrophages and lymphocytes, leading to the augmented production of pro-inflammatory adipokines and vasoconstrictors that induce endothelial dysfunction and vascular inflammation through their paracrine and endocrine actions. By contrast, the secretion of adiponectin, an adipokine with insulin sensitizing and anti-inflammatory activities, is decreased in obesity and its related pathologies. Emerging evidence suggests that adiponectin is protective against vascular dysfunction induced by obesity and diabetes, through its multiple favourable effects on glucose and lipid metabolism as well as on vascular function. Adiponectin improves insulin sensitivity and metabolic profiles, thus reducing the classical risk factors for cardiovascular disease. Furthermore, adiponectin protects the vasculature through its pleiotropic actions on endothelial cells, endothelial progenitor cells, smooth muscle cells and macrophages. Data from both animal and human investigations demonstrate that adiponectin is an important component of the adipo-vascular axis that mediates the cross-talk between adipose tissue and vasculature. This review highlights recent work on the vascular protective activities of adiponectin and discusses the molecular pathways underlying the vascular actions of this adipokine. |
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Authors:
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F Y L Li; K K Y Cheng; K S L Lam; P M Vanhoutte; A Xu |
Publication Detail:
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Type: Journal Article Date: 2010-12-08 |
Journal Detail:
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Title: Acta physiologica (Oxford, England) Volume: 203 ISSN: 1748-1716 ISO Abbreviation: Acta Physiol (Oxf) Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101262545 Medline TA: Acta Physiol (Oxf) Country: England |
Other Details:
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Languages: eng Pagination: 167-80 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors. Acta Physiologica © 2010 Scandinavian Physiological Society. |
Affiliation:
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Department of Medicine, University of Hong Kong, Hong Kong Research Center for Heart, Brain, Hormones, and Healthy Aging, University of Hong Kong, Hong Kong Department of Pharmacology and Pharmacy, University of Hong Kong, Hong Kong. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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