| Cross-talk between N-methyl-D-aspartate and adrenergic neurotransmission in the regulation of hypothalamic GnRH gene expression. | |
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MedLine Citation:
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PMID: 8062098 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although it has been known that activation of N-methyl-D-aspartate (NMDA) receptor effectively stimulates GnRH biosynthesis and release from the rat hypothalamus, no evidence that NMDA receptors exist in GnRH neurons is yet available. It is then presumed that the action of NMDA on GnRH neurons may be indirectly mediated through interneurons, such as catecholamines. The present study is designed to investigate whether the effect of NMDA on GnRH gene expression is mediated by adrenergic neuronal system. Adrenergic receptor antagonists were administered 30 min prior to NMDA administration to immature male rats and then animals sacrificed 60 min after NMDA administration. GnRH mRNA levels were determined by Northern blot analysis using a GnRH RNA probe. Inhibition of either alpha 1 adrenergic receptor with prazosin or beta adrenergic receptor with propranolol did not cause any change in the basal GnRH mRNA levels but reduced NMDA-induced GnRH mRNA levels. However, inhibition of alpha 2 adrenergic receptor with yohimbine increased GnRH mRNA levels but did not affect NMDA-induced GnRH mRNA levels. These findings suggest that the effect of NMDA on GnRH gene expression is mediated through adrenergic neurotransmission. |
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Authors:
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J Suh; E S Song; C Kim; M H Yu; K Kim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research Volume: 645 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1994 May |
Date Detail:
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Created Date: 1994-09-21 Completed Date: 1994-09-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 36-40 Citation Subset: IM |
Affiliation:
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Department of Molecular Biology, Seoul National University, South Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Gene Expression / drug effects* Gonadotropin-Releasing Hormone / genetics* Hypothalamus / physiology* Male N-Methylaspartate / pharmacology* RNA, Messenger / metabolism Rats Rats, Sprague-Dawley Sympathetic Nervous System / physiology* Sympatholytics / pharmacology Synaptic Transmission / physiology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; 0/Sympatholytics; 33515-09-2/Gonadotropin-Releasing Hormone; 6384-92-5/N-Methylaspartate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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