Document Detail

Cross-spectral analysis of cardiovascular variables in supine diabetic patients.
MedLine Citation:
PMID:  15834765     Owner:  NLM     Status:  MEDLINE    
Cardiovascular autonomic neuropathy in diabetes is associated with a high risk of mortality, which makes its early identification clinically important. An easy method for identification of subjects with autonomic dysfunction would be of clinical benefit. We evaluated the autonomic function in 28 diabetic patients and 21 control subjects recording 12 min time series of heart period (RR) and systolic arterial pressure (SAP, Finapres) during supine rest and 60 degrees head-up tilt. The power of the high (respiratory) and low (LF approximately 0.1 Hz) frequency oscillations was quantified by spectral analysis. The central frequency of the LF oscillations (LF_freq), phase shift, and the transfer function gain between RR interval and SAP fluctuations were provided by cross-spectral analysis, and measured at the point of maximal coherence. In the supine position 15 patients (LF-) displayed atypical LF variability with the LF_freq being shifted towards lower frequencies (about 0.06 Hz). They also showed larger phase angle, lower values or even absence of coherence and smaller transfer function gain between RR and SAP fluctuations. 13 patients (LF+) and the controls showed the LF_freq around 0.1 Hz, higher coherence and transfer function gain values. The orthostatic maneuver induced the expected changes in the spectral parameters (increase in the LF components of both RR and SAP and decrease in the HF variability of RR) into the LF+ patients and all the control subjects and abnormal response in the other 15 LF-patients. These findings indicate that diabetic subjects with uncharacteristic response to the orthostatic test present abnormal LF variability already in the supine position. Crossspectral parameters while supine may be used for the identification of these subjects.
G Gulli; Bruno Fattor; Mario Marchesi
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Clinical autonomic research : official journal of the Clinical Autonomic Research Society     Volume:  15     ISSN:  0959-9851     ISO Abbreviation:  Clin. Auton. Res.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-18     Completed Date:  2005-07-27     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  9106549     Medline TA:  Clin Auton Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  92-8     Citation Subset:  IM    
Institute for Cardiovascular Research, University of Leeds, Worsley dental Building, Leeds LS2 9JT, UK.
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MeSH Terms
Autonomic Nervous System Diseases / diagnosis,  physiopathology
Blood Pressure / physiology
Diabetes Mellitus / physiopathology*
Diabetic Neuropathies / diagnosis,  physiopathology
Heart Rate / physiology
Hemodynamics / physiology*
Middle Aged
Supine Position

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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