Document Detail


Cross-sectional and longitudinal associations of neighborhood characteristics with inflammatory markers: findings from the multi-ethnic study of atherosclerosis.
MedLine Citation:
PMID:  20667763     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated cross-sectional associations of neighborhood deprivation, problems, safety, and cohesion with circulating levels of fibrinogen, interleukin-6, and C-reactive protein (n = 5370) and longitudinal associations with changes in IL-6 over a 3-4 year period (n = 946). In cross-sectional analyses, higher levels of neighborhood deprivation and problems were associated with higher levels of all three inflammatory markers, whereas higher levels of safety were associated with lower levels. Fibrinogen remained associated with all neighborhood characteristics except cohesion and IL-6 remained associated with safety after adjustment for race and SES. In longitudinal analyses, higher levels of neighborhood deprivation and problems, and lower levels of safety were associated with greater longitudinal increases in IL-6 after adjustment for age, sex, race, and SES. These findings were not substantially modified by further risk factor adjustment. Although findings regarding different inflammatory markers were mixed, the longitudinal results that are less limited by race confounding suggest that inflammatory pathways may contribute to neighborhood differences in cardiovascular disease risk.
Authors:
Aydin Nazmi; Ana Diez Roux; Nalini Ranjit; Teresa E Seeman; Nancy S Jenny
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-07-18
Journal Detail:
Title:  Health & place     Volume:  16     ISSN:  1873-2054     ISO Abbreviation:  Health Place     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-11     Completed Date:  2011-03-30     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  9510067     Medline TA:  Health Place     Country:  England    
Other Details:
Languages:  eng     Pagination:  1104-12     Citation Subset:  T    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA. nazmi@calpoly.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Atherosclerosis / blood*,  ethnology,  immunology
Biological Markers / analysis
C-Reactive Protein / analysis
Cross-Sectional Studies
Female
Fibrinogen / analysis
Humans
Inflammation / blood*
Interleukin-6 / blood
Male
Middle Aged
Poverty Areas*
Residence Characteristics*
Grant Support
ID/Acronym/Agency:
N01-HC-95159/HC/NHLBI NIH HHS; N01-HC-95165/HC/NHLBI NIH HHS; N01-HC-95169/HC/NHLBI NIH HHS; P60 MD002249/MD/NIMHD NIH HHS; P60 MD002249-04/MD/NIMHD NIH HHS; R01 HL076831-04/HL/NHLBI NIH HHS; R01 HL76831/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-6; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein
Comments/Corrections

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