| Cross-sectional area and volume compliance of porcine left coronary arteries. | |
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MedLine Citation:
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PMID: 11454565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have determined the cross-sectional area (CSA) compliance of the first several generations of pig coronary arteries and the volume compliance of the coronary arterial tree (vessels >0.5 mm in diameter) using a videodensitometric technique. The coronary arteries of four KCl-arrested maximally vasodilated pig hearts were perfused with iodine and 3% Cab-O-Sil. Because Cab-O-Sil occludes small arteries, the flow can be stopped and the pressure can be maintained while the trunk of the coronary artery and its subbranches are imaged using digital angiography. The coronary arteries were preconditioned several times with cyclic changes in pressure from 0 to 160 mmHg. The pressure was then varied in a triangular pattern, and the absolute CSA of each vessel and the total arterial volume were calculated using videodensitometry in conjunction with digital subtraction angiography. Our results have shown that the pressure-diameter and pressure-volume relationships are linear in the 60-140 mmHg pressure range. Furthermore, the compliance of the coronary arteries is small; i.e., the diameter of the coronary artery changes by <15% in the 80-mmHg pressure range. The compliance data couples the mechanics of the blood vessel wall to the mechanics of blood flow to yield a pressure-flow relationship for each coronary arterial segment. |
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Authors:
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G S Kassab; S Molloi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 281 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-07-16 Completed Date: 2001-08-16 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H623-8 Citation Subset: IM |
Affiliation:
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Department of Bioengineering, University of California, La Jolla, California 92093-0412, USA. kassab@bioemg.ucsd.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biomechanics Blood Pressure / physiology Coronary Vessels / cytology, physiology* Regional Blood Flow / physiology Swine |
| Grant Support | |
ID/Acronym/Agency:
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5-R29-HL-55554/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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