Document Detail

Cross-sectional analysis of a collaborative Web-based database for lupus erythematosus-associated skin lesions: prospective enrollment of 114 patients.
MedLine Citation:
PMID:  19289753     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To assess disease severity in subsets of patients with cutaneous lupus erythematosus (CLE) by using outcome and quality-of-life measures, and to determine treatment responsiveness by establishing a Web-based database of patients with skin manifestations of lupus.
DESIGN: Prospective, cross-sectional study.
SETTING: University hospital cutaneous autoimmunity outpatient clinic.
PATIENTS: One hundred fourteen patients who presented from January 15, 2007, to November 8, 2007, and met the criteria for having CLE or lupus-nonspecific skin disease.
MAIN OUTCOME MEASURES: Scores on the CLE Disease Activity and Severity Index and the modified Skindex-29 (a quality-of-life measure) completed at each visit.
RESULTS: Seven patients (6.1%) presented with acute CLE, 21 (18.4%) with subacute CLE, 77 (67.5%) with chronic CLE, 7 (6.1%) with systemic lupus erythematosus and LE-nonspecific skin lesions, and 1 (0.9%) with LE-nonspecific skin disease only. The mean baseline CLE Disease Activity and Severity Index activity/damage scores in patients with acute, subacute, and chronic CLE were 6.4/5.1, 11.1/1.6, and 7.5/10.2, respectively. The mean baseline modified Skindex-29 scores were 76.3, 79.4, and 82.7, respectively (P = .80). The disease in 11 of the patients (9.6%) was considered refractory to conventional therapies. Significantly more patients in the refractory group than the nonrefractory group were current smokers (P = .006).
CONCLUSION: This Web-based database should allow collection of data related to disease activity, quality of life, and response to therapy at multiple centers.
Siamak Moghadam-Kia; Katherine Chilek; Elizabeth Gaines; Melissa Costner; Mathew E Rose; Joyce Okawa; Victoria P Werth
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Archives of dermatology     Volume:  145     ISSN:  1538-3652     ISO Abbreviation:  Arch Dermatol     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-17     Completed Date:  2009-04-10     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  255-60     Citation Subset:  AIM; IM    
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MeSH Terms
Age of Onset
Cross-Sectional Studies
Databases, Factual*
Lupus Erythematosus, Cutaneous / pathology*
Middle Aged
Quality of Life
Sex Ratio
Grant Support
K24 AR002207/AR/NIAMS NIH HHS; K24 AR002207-06A2/AR/NIAMS NIH HHS; K24-AR 02207/AR/NIAMS NIH HHS; T32-AR007465-25/AR/NIAMS NIH HHS
Comment In:
Arch Dermatol. 2009 Mar;145(3):316-9   [PMID:  19289766 ]

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