| Cross-reactivity patterns of T cells specific for iodinated contrast media. | |
| | |
MedLine Citation:
|
PMID: 17412404 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Approximately 3% of patients exposed to iodinated contrast media develop delayed hypersensitivity reactions. OBJECTIVE: We wanted to better understand the molecular basis of contrast media cross-reactivity. METHODS: Cross-reactivity was assessed by skin testing and measurement of T-cell activation (CD69 upregulation) and proliferation ((3)H-thymidine uptake, 5,6-carboxyfluorescein diacetate succinimidyl ester staining) of PBMCs, T-cell lines, and T-cell clones of 2 patients with delayed hypersensitivity reactions to iohexol and iomeprol, respectively. Thirteen different contrast media and potassium iodide were compared. RESULTS: Skin testing and analyses of PBMCs, T-cell lines, and clones showed broad cross-reactivity in both patients. Broad as well as more restricted cross-reactivity patterns were found in iohexol-specific and iomeprol-specific CD4(+) T-cell clones, whereas 1 iomeprol-specific CD8(+) T-cell clone showed no cross-reactivity at all. The reactivity to equimolar concentrations of iohexol and its dimer iodixanol was very similar, suggesting that the dimer was not more stimulatory than its monomer. Consistently low reactivity to iobitridol was found in both patients, but never to iodide. A frequency analysis of contrast medium-specific peripheral T cells gave values between 0.6 % (iomeprol) and 0.05 % (iobitridol). CONCLUSION: Clinically observed cross-reactivity between different contrast media is a result of the presence of contrast media-specific T cells, some of which show a broad cross-reactivity pattern. Iodide ions, known to be present at low concentration in contrast media solutions, do not seem to be the causative moiety. CLINICAL IMPLICATIONS: Detailed in vitro analysis might help identify noncross-reactive contrast media. |
| | |
Authors:
|
Marianne Lerch; Monika Keller; Markus Britschgi; Gisele Kanny; Valerie Tache; Daphne A Schmid; Andreas Beeler; Basil O Gerber; Michael Luethi; Andreas J Bircher; Cathrine Christiansen; Werner J Pichler |
Related Documents
:
|
16614714 - The effect of hypoxia on photocytotoxicity of tics tricarbocyanine dye in vitro. 19298354 - Photodynamic inactivation of candida albicans by bam-sipc. 17951254 - Light and oxygen are not required for harpin-induced cell death. 18161554 - Feasibility of using microbial fuel cell technology for bioremediation of hydrocarbons ... 11912144 - Selective sensitization of transformed cells to flavopiridol-induced apoptosis followin... 2174814 - Dna damage and lethal effects of hydrogen peroxide and menadione in chinese hamster cel... |
Publication Detail:
|
Type: Case Reports; Comparative Study; Journal Article Date: 2007-04-06 |
Journal Detail:
|
Title: The Journal of allergy and clinical immunology Volume: 119 ISSN: 0091-6749 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 2007 Jun |
Date Detail:
|
Created Date: 2007-06-08 Completed Date: 2007-07-27 Revised Date: 2012-01-11 |
Medline Journal Info:
|
Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: United States |
Other Details:
|
Languages: eng Pagination: 1529-36 Citation Subset: AIM; IM |
Affiliation:
|
Clinic for Rheumatology and Clinical Immunology/Allergology, Inselspital, University of Bern, Bern, Switzerland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Cell Line Clone Cells Contrast Media / adverse effects* Female Humans Hypersensitivity, Delayed / chemically induced, immunology* Iohexol / adverse effects*, diagnostic use Iopamidol / adverse effects, analogs & derivatives*, diagnostic use Lymphocyte Activation / drug effects, immunology Male Middle Aged Skin Tests T-Lymphocytes / drug effects*, immunology* Triiodobenzoic Acids / diagnostic use, immunology |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 0/Triiodobenzoic Acids; 62883-00-5/Iopamidol; 66108-95-0/Iohexol; 78649-41-9/iomeprol; 92339-11-2/iodixanol |
| Comments/Corrections | |
Comment In:
|
J Allergy Clin Immunol. 2011 Dec;128(6):1356-7
[PMID:
21782229
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prenatal versus postnatal sensitization to environmental allergens in a high-risk birth cohort.
Next Document: Connective tissue growth factor expression is regulated by histamine in lung fibroblasts: potential ...