Document Detail

Cross-reactivity between penicillins and cephalosporins: clinical and immunologic studies.
MedLine Citation:
PMID:  2918183     Owner:  NLM     Status:  MEDLINE    
Nineteen well-characterized penicillin-allergic patients were investigated for their sensitivity to cephalosporins containing potentially cross-reactive side chains. All patients were administered cephamandole parenterally and, if this was tolerated, a course of oral cephaloridine was administered. Only two patients responded to the cephamandole; none of the remaining patients reacted to cephaloridine. Benzylpenicilloyl RAST-inhibition studies with sera from three subjects who had not reacted to the cephalosporins demonstrated that cephamandole linked to proteins was capable of recognizing benzylpenicilloyl-specific IgE antibody. It is concluded that consideration of side chain structures can help to predict possible cross-reactions between penicillins and cephalosporins, but carefully controlled challenge tests are advisable before penicillin-allergic patients are treated with cephalosporins. In relation to cross-reacting potential, in vitro experimental studies are difficult to interpret and may in some circumstances overestimate the risk.
M Blanca; J Fernandez; A Miranda; S Terrados; M J Torres; J M Vega; M J Avila; E Perez; J J Garcia; R Suau
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  83     ISSN:  0091-6749     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-04-03     Completed Date:  1989-04-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  381-5     Citation Subset:  AIM; IM    
Allergy Section, Carlos Haya Hospital, Malaga, Spain.
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MeSH Terms
Amoxicillin / administration & dosage,  adverse effects,  immunology
Ampicillin / administration & dosage,  adverse effects,  immunology
Binding, Competitive
Cephalosporins / administration & dosage*,  adverse effects,  immunology
Cross Reactions*
Drug Hypersensitivity / etiology*,  immunology
Intradermal Tests
Middle Aged
Penicillin G / administration & dosage,  adverse effects,  immunology
Penicillins / administration & dosage*,  adverse effects,  immunology
Radioallergosorbent Test
Reg. No./Substance:
0/Cephalosporins; 0/Penicillins; 26787-78-0/Amoxicillin; 61-33-6/Penicillin G; 69-53-4/Ampicillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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