Document Detail


Cross-reactive antibodies against GM2 and CMV-infected fibroblasts in Guillain-Barré syndrome.
MedLine Citation:
PMID:  10751257     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate whether anti-GM2 antibodies in patients with Guillain-Barré syndrome (GBS) are induced by molecular mimicry with cytomegalovirus (CMV). BACKGROUND: Antibodies against ganglioside GM2 are frequently present in the serum from GBS patients with an antecedent infection with CMV. METHODS: The authors detected inhibition of anti-GM2 reactivity after incubation of GM2-reactive serum samples with fibroblasts infected with a GBS-associated CMV strain. Control sera consisted of GQ1b-reactive samples, and control antigens included uninfected fibroblasts and fibroblasts that were infected with other herpes viruses. RESULTS: Serum immunoglobulin M reactivity with GM2 was decreased in a dose-dependent manner after incubation with CMV-infected fibroblasts. Incubation of anti-GM2-positive serum samples with uninfected fibroblasts and fibroblasts infected with varicella zoster virus did not inhibit anti-GM2 reactivity, whereas this reactivity was slightly decreased after incubation with herpes simplex virus type 1 in one patient. Antibodies against ganglioside GQ1b did not react with CMV-infected fibroblasts. CONCLUSIONS: CMV-infected fibroblasts express gangliosidelike epitopes that recognize specifically anti-GM2 antibodies. These results support the hypothesis that antiganglioside antibodies in CMV-infected GBS patients are induced by molecular mimicry between GM2 and antigens that are induced by a CMV infection.
Authors:
C W Ang; B C Jacobs; A H Brandenburg; J D Laman; F G van der Meché; A D Osterhaus; P A van Doorn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  54     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-05-04     Completed Date:  2000-05-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1453-8     Citation Subset:  AIM; IM    
Affiliation:
Departments of Neurology, Erasmus University Rotterdam, The Netherlands. ANG@neuro.fgg.eur.nl
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antibody Specificity / immunology
Autoantibodies / blood*
Cross Reactions / immunology
Cytomegalovirus / immunology*
Cytomegalovirus Infections / complications,  immunology*
Dose-Response Relationship, Immunologic
Enzyme-Linked Immunosorbent Assay
Female
Fibroblasts / cytology,  immunology,  virology*
G(M1) Ganglioside / immunology
G(M2) Ganglioside / immunology*
Guillain-Barre Syndrome / blood,  immunology*,  virology
Herpesvirus 1, Human / immunology
Herpesvirus 3, Human / immunology
Humans
Immunosorbent Techniques
Serologic Tests
Chemical
Reg. No./Substance:
0/Autoantibodies; 19600-01-2/G(M2) Ganglioside; 37758-47-7/G(M1) Ganglioside

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