Document Detail

Cross-reactive T-cell antigens among mammalian species.
MedLine Citation:
PMID:  59778     Owner:  NLM     Status:  MEDLINE    
Fluoresceinated heteroantisera prepared against T cells of rats, monkeys, and humans were reacted withthymus and spleen cells from 11 selected species. These reagents recognized cross-reacting T cell antigen(s) among rodent species (mouse, rat, guinea pig, and hamster) and among primate species (monkey and humans). With one exception, the cross-reactivity was restricted to a phylogenetic order. All three antisera required relatively few absorptions to achieve T cell specificity for related species when compared to absorption requirements for the isologous species. Differentiation antigens within a phylogenetic order thus appear to be more homologous than other cell surface constituents on T cells.
C M Balch; M K Dagg; M D Cooper
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  117     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  1976 Aug 
Date Detail:
Created Date:  1976-10-02     Completed Date:  1976-10-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  447-9     Citation Subset:  AIM; IM    
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MeSH Terms
Antilymphocyte Serum
Cross Reactions
Species Specificity
Spleen / cytology
T-Lymphocytes / immunology*
Thymus Gland / cytology
Reg. No./Substance:
0/Antigens; 0/Antilymphocyte Serum; 0/Epitopes

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