Document Detail

Cross-over trials with censored data.
MedLine Citation:
PMID:  8783435     Owner:  NLM     Status:  MEDLINE    
Cross-over trials assign two or more treatments sequentially to the same subject; groups of subjects receive different treatment sequences. Both parametric and non-parametric methods of inference are available for cross-over trials with complete data. In this paper we develop methods for estimation and testing in cross-over trials with censored data, based partly on methods used for complete data. Our estimator is consistent for the true effects. Simulation results show that both of our proposed tests have approximately nominal size. We compare our procedures to a method for cross-over designs based on Cox regression proposed by France, Lewis and Kay. We demonstrate that our method of estimation is superior to the Cox-based method, which has considerable bias. Both of the tests presented here have more power than the Cox-based tests in all of the situations we investigated. The estimation and test procedures apply to other designs, such as parallel trials and repeated measures designs.
M Feingold; B W Gillespie
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Statistics in medicine     Volume:  15     ISSN:  0277-6715     ISO Abbreviation:  Stat Med     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-12-05     Completed Date:  1996-12-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8215016     Medline TA:  Stat Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  953-67     Citation Subset:  IM    
Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor 48109-2029, USA.
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MeSH Terms
Bias (Epidemiology)
Cross-Over Studies*
Data Collection
Data Interpretation, Statistical*
Linear Models
Models, Statistical
Regression Analysis
Statistics, Nonparametric

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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