| Cross-link immunoprecipitation data to detect polymorphisms lying in splicing regulatory motifs: a method to refine single nucleotide polymorphism selection in association studies. | |
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MedLine Citation:
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PMID: 21946076 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In a previous study we showed that prediction tools are useful to select single-nucleotide polymorphisms (SNPs) which potentially affect phenotype and therefore guide genotyping in association studies, thus saving time and money. Here we use the recently available RNA cross-link immunoprecipitation data to analyze several genes involved in psychiatric disorders and show which disease-associated SNPs can affect the splicing process by altering splicing factor binding sites. We point out the importance of using cross-link immunoprecipitation data in psychiatry to refine the SNP selection methods, to explain the association found and to plan molecular investigations. |
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Authors:
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Francesco Piva; Matteo Giulietti; Tatiana Armeni; Giovanni Principato |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-23 |
Journal Detail:
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Title: Psychiatric genetics Volume: - ISSN: 1473-5873 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9106748 Medline TA: Psychiatr Genet Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Specialized Clinical Sciences and Odontostomatology, Polytechnic University of Marche, Ancona, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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