Document Detail


Cross immunological reactions between three haptens of the "para" group and 4-aminoantipyrine.
MedLine Citation:
PMID:  117463     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cross passive hemagglutination reactions between sulfanilic acid (SA), para-aminobenzoic acid (PABA), p-phenethidine (PT) and 4-aminoantipyrine (4-AA) haptens have been investigated using conjugates of diazo derivaties of these compounds with homologous serum proteins. Intense cross passive hemagglutination reactions were found between PABA, SA and 4-AA haptens. Although anti-PT sera cross reacted intensely with PABA, SA as well as with 4-AA haptens, antibodies cross reacting with PT were not detected in any of the anti-PABA, anti-SA and anti-4-AA antisera. The conjugates containing a heterologous hapten de not substantially alter the titer of the hemagglutination reactions performed with erythrocytes coated with the homologous hapten, but completely suppress the hemagglutination reactions performed with erythrocytes coated with this hapten as well as with other, but not all, heterologous, haptens. The results support the conclusion that the apparent polysensitization to drugs may actually rely upon cross reactions with haptens chemically related to the immunizing one.
Authors:
M Cîrstea; G Suhaciu; M Cîrje
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiologie     Volume:  16     ISSN:  1011-6206     ISO Abbreviation:  Physiologie     Publication Date:    1979 Apr-Jun
Date Detail:
Created Date:  1980-02-15     Completed Date:  1980-02-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7510964     Medline TA:  Physiologie     Country:  ROMANIA    
Other Details:
Languages:  eng     Pagination:  103-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
4-Aminobenzoic Acid / immunology*
Aminobenzoic Acids / immunology*
Aminophenols / immunology*
Ampyrone / immunology*
Animals
Antibodies / analysis
Antibody Specificity
Antipyrine / analogs & derivatives*
Benzenesulfonates / immunology*
Cross Reactions
Female
Haptens / immunology*
Hemagglutination Tests
Male
Phenetidine / immunology*
Rabbits
Sulfanilic Acids / immunology*
Chemical
Reg. No./Substance:
0/Aminobenzoic Acids; 0/Aminophenols; 0/Antibodies; 0/Benzenesulfonates; 0/Haptens; 0/Sulfanilic Acids; 150-13-0/4-Aminobenzoic Acid; 156-43-4/Phenetidine; 60-80-0/Antipyrine; 83-07-8/Ampyrone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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