Document Detail


Cross-correlation of fetal cardiac and somatic activity as an indicator of antenatal neural development.
MedLine Citation:
PMID:  11744919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: In this study, we wanted to model the emergence of coupling between fetal cardiac and somatic activity in normal and at-risk fetuses. STUDY DESIGN: One hundred six fetuses of uncomplicated pregnancies were longitudinally monitored at 20, 24, 28, 32, 36, and 38 weeks of gestation by using a fetal actocardiograph and computerized data collection. Twenty-six fetuses of complicated pregnancies were also included. Statistical time series analysis techniques were used to examine the relation between fetal movement and fetal heart rate. RESULTS: A linear increase was found in the magnitude of the cross-correlation function between fetal movement and fetal heart rate as gestation advanced, with coalescence around a peak lag of 5 seconds by 32 weeks. Fetuses that delivered before term evidenced accelerated fetal movement and fetal heart rate coupling, whereas fetuses affected by deleterious conditions showed a decline in developmental trajectory. CONCLUSIONS: The cross-correlation between fetal cardiac and somatic activity is an indicator of neuroregulation in human fetuses.
Authors:
J A Dipietro; R A Irizarry; M Hawkins; K A Costigan; E K Pressman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  185     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-17     Completed Date:  2002-01-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1421-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Population and Health Sciences, Johns Hopkins University, Baltimore, MD 21205, USA. jdipietr@jhsph.edu
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MeSH Terms
Descriptor/Qualifier:
Embryonic and Fetal Development
Female
Fetal Diseases / physiopathology
Fetal Movement*
Gestational Age
Heart Rate, Fetal*
Humans
Infant, Newborn
Infant, Premature
Nervous System / embryology*
Grant Support
ID/Acronym/Agency:
HD R01 27592/HD/NICHD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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