Document Detail


Cross-clade CD8 T-cell responses to HIV(IIIB) and Chinese B' and C/B' viruses in North American and Chinese HIV-seropositive donors.
MedLine Citation:
PMID:  15602120     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HIV variation presents an obstacle to a global AIDS vaccine. Viral diversity and host variations in MHC expression both affect vaccine responses. Whether CD8 T cells from HIV-infected donors in 1 part of the world cross-recognize isolates from other regions will provide guidance about whether country-specific vaccines are needed. We compared recognition of HIV(IIIB) and representative B' (Thai B) and recombinant C/B' virus strains endemic in China by CD8 T cells from 7 HIV-infected North American donors and 4 Chinese donors. IFN-gamma production in response to HIV(IIIB) or the Chinese viruses was comparable. Although 1.6 +/- 0.8% of American donor CD8 T cells produced IFN-gamma above the background level in response to IIIB virus, 1.5 +/- 0.8% responded to B' virus, and 1.4 +/- 0.7% responded to C/B' virus. Responses to adherent cells infected with vaccinia viruses expressing B' and C/B' virus gag and env were also comparable in magnitude with responses to IIIB virus. Cytolysis of CD4 T cells infected with B' virus was comparable with lysis of cells infected with IIIB virus, but lysis of the more divergent C/B' virus was somewhat reduced. T cells, selected for IFN-gamma production to IIIB virus, also efficiently lysed cells infected with Chinese viruses. Therefore, cross-clade CD8 T-cell responses to IIIB virus and prevalent Chinese viral strains are common.
Authors:
Vanessa François-Bongarcon; Yi Feng; Sang-Kyung Lee; Gang Chen; Premlata Shankar; Ying Liu; Xin Tao; Yiming Shao; Judy Lieberman
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  37     ISSN:  1525-4135     ISO Abbreviation:  J. Acquir. Immune Defic. Syndr.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-16     Completed Date:  2006-01-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1435-44     Citation Subset:  IM; X    
Affiliation:
CBR Institute for Biomedical Research, Boston, Massachusetts 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
AIDS Vaccines / immunology*
CD4-Positive T-Lymphocytes / virology
CD8-Positive T-Lymphocytes / immunology*,  virology
Cells, Cultured
China
Cross Reactions
Genes, Viral
HIV / genetics,  immunology*
HIV Antigens / immunology
HIV Seropositivity / diagnosis,  immunology*
Humans
Interferon-gamma / biosynthesis*
Macrophages / virology
North America
T-Lymphocytes, Cytotoxic / immunology*
Vaccinia virus / genetics
Grant Support
ID/Acronym/Agency:
U19 AI51915/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/AIDS Vaccines; 0/HIV Antigens; 82115-62-6/Interferon-gamma

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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