Document Detail

Cross-antigenicity between penams and cephems by intradermal skin test and leucocyte migration test in guinea pigs.
MedLine Citation:
PMID:  2273447     Owner:  NLM     Status:  MEDLINE    
The delayed-type hypersensitivity (DTH) reactions for penams or cephems of beta-lactam antibiotics were investigated by intradermal skin test and leucocyte migration test (LMT) in guinea pigs. The animals were immunized with ampicillin (ABPC) or cephalexin (CEX) using Freund's complete adjuvant. The cross-reactivities among ABPC, penicillin G (PCG) and cloxacillin as penam and CEX, cephalothin (CET) and cephalosporin C (CEPC) as cephem and phenylglycine (PhGly), which is the amino acyl side chain of ABPC and CEX, were examined. By intradermal reaction, ABPC-sensitized animals showed a cross-reaction with CEX, PCG and CET, but CEX-sensitized animals did not cause cross-reaction with ABPC. The CEX-sensitized group exhibited slight cross-reactions to CET and PhGly. PhGly exhibited low immunogenicity only in maximization test of guinea pig. The above results indicate that there is the difference in cross-reactivity between penams and cephems in skin test. In LMT, all the ABPC-sensitized animals reacted with ABPC and showed cross-reactions with all drugs tested. The CEX-sensitized group reacted with 4 out of 7 animals with CEX and exhibited cross-reactivities to ABPC, PCG, CET, CEPC and PhGly. The cross-reactivity between intradermal skin reaction and LMT elicited some different results.
N Nagakura; T Kobayashi; T Shimizu; T Masuzawa; Y Yanagihara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmacobio-dynamics     Volume:  13     ISSN:  0386-846X     ISO Abbreviation:  J. Pharmacobio-dyn.     Publication Date:  1990 May 
Date Detail:
Created Date:  1991-02-25     Completed Date:  1991-02-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7901854     Medline TA:  J Pharmacobiodyn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  310-5     Citation Subset:  IM    
Department of Microbiology, School of Pharmaceutical Sciences, University of Shizuoka, Japan.
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MeSH Terms
Ampicillin / immunology
Anti-Bacterial Agents / immunology*
Anti-Inflammatory Agents, Non-Steroidal / immunology
Antigens / immunology
Cell Migration Inhibition
Cephalexin / immunology
Cephalosporins / immunology
Cephalothin / immunology
Cloxacillin / immunology
Cross Reactions / immunology*
Drug Hypersensitivity
Glycine / analogs & derivatives,  immunology
Guinea Pigs
Hypersensitivity, Delayed / chemically induced
Penicillin G / immunology
Skin Tests / methods
Structure-Activity Relationship
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antigens; 0/Cephalosporins; 153-61-7/Cephalothin; 15686-71-2/Cephalexin; 56-40-6/Glycine; 61-24-5/cephalosporin C; 61-33-6/Penicillin G; 61-72-3/Cloxacillin; 69-53-4/Ampicillin; 69-91-0/2-phenylglycine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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