Document Detail

Cross allergy between paranitro compounds with special reference to DNCB and chloramphenicol.
MedLine Citation:
PMID:  657786     Owner:  NLM     Status:  MEDLINE    
Cross allergy between paranitro compounds including DNCB and chloramphenicol, was studied in 42 patients. A total of 27 had been primarily sensitized to DNCB, and 15 patients with eczema exhibited a delayed-type reaction to chloramphenicol, showing a positive patch test. All 15 patients with chloramphenicol allergy cross reacted with chloramphenicol succinate and chloramphenicol palmitate. Three of them cross reacted with paranitrobenzoic acid, and two of these also with paradinitrobenzene. None of the 15 patients cross reacted with DNCB in acetone or DNCB in petrolatum, and none reacted to picric acid, paranitrophenol or dinitroorthocresol. The 27 patients primarily sensitized to DNCB did not cross react with any of the paranitro compounds studied, in particular not with chloramphenicol or its salts. Thus, the study confirms the specificity of the DNCB sensitivity.
K Eriksen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Contact dermatitis     Volume:  4     ISSN:  0105-1873     ISO Abbreviation:  Contact Derm.     Publication Date:  1978 Feb 
Date Detail:
Created Date:  1978-08-14     Completed Date:  1978-08-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  29-32     Citation Subset:  IM    
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MeSH Terms
Chloramphenicol / immunology*
Cross Reactions
Dinitrochlorobenzene / immunology*
Drug Hypersensitivity / etiology,  immunology*
Eczema / immunology
Hypersensitivity, Delayed / etiology
Middle Aged
Nitro Compounds / immunology*
Nitrobenzenes / immunology*
Reg. No./Substance:
0/Nitro Compounds; 0/Nitrobenzenes; 56-75-7/Chloramphenicol; 97-00-7/Dinitrochlorobenzene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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