| Cross-validation of a new procedure for early screening of smoking cessation medications in humans. | |
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MedLine Citation:
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PMID: 20485335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Brief procedures for evaluating medication efficacy may reveal which candidate drugs warrant further testing in clinical trials and which do not. We previously carried out a study of smoking abstinence, involving the nicotine patch, and established the sensitivity of our procedure. In this study, we sought to cross-validate our earlier work by comparing short-term smoking abstinence due to varenicline (relative to placebo) in smokers with high intrinsic quit interest (n = 57) and those with low intrinsic quit interest (n = 67). All the subjects were randomly assigned to either abstinence reinforcement ($12/day) or no reinforcement. In a crossover design, all the subjects participated in two 3-week phases: ad libitum smoking (week 1), dose run-up of varenicline (1.0 mg b.i.d.) or placebo (week 2), and quit attempt on medication verified daily by carbon monoxide <5 ppm (week 3). As with the nicotine patch in the previous study, varenicline (relative to placebo) increased abstinence more effectively in those with high intrinsic quit interest than in those with low quit interest but did not affect abstinence due to reinforcement. These data confirm the feasibility of a brief, sensitive test of the efficacy of cessation medications in smokers with high quit interest. |
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Authors:
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K A Perkins; C Lerman; C A Fonte; M Mercincavage; M L Stitzer; K N R Chengappa; A Jain |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Validation Studies Date: 2010-05-19 |
Journal Detail:
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Title: Clinical pharmacology and therapeutics Volume: 88 ISSN: 1532-6535 ISO Abbreviation: Clin. Pharmacol. Ther. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-21 Completed Date: 2010-07-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372741 Medline TA: Clin Pharmacol Ther Country: United States |
Other Details:
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Languages: eng Pagination: 109-14 Citation Subset: AIM; IM |
Affiliation:
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Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. perkinska@upmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Adult Benzazepines / adverse effects, therapeutic use* Cross-Over Studies Data Interpretation, Statistical Double-Blind Method Drug Evaluation, Preclinical Female Humans Male Motivation Nicotine / administration & dosage, adverse effects, therapeutic use* Nicotinic Agonists / administration & dosage, adverse effects, therapeutic use* Questionnaires Quinoxalines / adverse effects, therapeutic use* Reproducibility of Results Research Design Smoking / psychology Smoking Cessation / methods* |
| Grant Support | |
ID/Acronym/Agency:
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P50CA143187/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Benzazepines; 0/Nicotinic Agonists; 0/Quinoxalines; 0/varenicline; 54-11-5/Nicotine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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