Document Detail

Cronkhite-Canada syndrome: report of two cases, biopsy findings in the associated alopecia, and a new treatment option.
MedLine Citation:
PMID:  9564598     Owner:  NLM     Status:  MEDLINE    
Two patients with Cronkhite-Canada syndrome (CCS) are reported, both of whom had diffuse alopecia, nail and skin changes, gastrointestinal polyposis, diarrhea, and wasting. A scalp biopsy was performed in one patient, and the specimen showed a marked noninflammatory loss of follicular units, miniaturization of the hair shafts, markedly dilated follicles, and a heavy deposition of glycosaminoglycans in the reticular dermis. This patient responded to prednisone therapy. The other patient was found to have elevated gastric acid levels and responded to ranitidine therapy. The conditions of both patients are now in remission two and six years later, respectively. Our patients have shown a temporally related remission of disease during treatment with prednisone and ranitidine, suggesting that each agent may be effective in CCS. However, randomized placebo-controlled trials are needed to prove the efficacy of these therapies. Further investigation of the histopathologic features of the associated alopecia may determine its cause.
J Allbritton; E Simmons-O'Brien; D Hutcheons; S E Whitmore
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cutis     Volume:  61     ISSN:  0011-4162     ISO Abbreviation:  Cutis     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-06-18     Completed Date:  1998-06-18     Revised Date:  2013-09-12    
Medline Journal Info:
Nlm Unique ID:  0006440     Medline TA:  Cutis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  229-32     Citation Subset:  IM    
Department of Dermatology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA.
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MeSH Terms
Alopecia / complications*,  drug therapy,  pathology
Glucocorticoids / therapeutic use
Intestinal Polyps / complications*,  drug therapy
Nail Diseases / complications
Prednisone / therapeutic use
Ranitidine / therapeutic use
Scalp / pathology*
Reg. No./Substance:
0/Glucocorticoids; 53-03-2/Prednisone; 66357-35-5/Ranitidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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