| Crohn's disease, sulfasalazine, and mycobacteria. | |
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MedLine Citation:
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PMID: 2567777 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The in vitro antimycobacterial activities of sulfasalazine and its split products, mesalazine (5-aminosalicylic acid) and sulfapyridine, against 170 mycobacterial strains belonging to 17 species were compared with those of diaminodiphenylsulfone, sulfadimethoxine, olsalazine, and para-aminosalicyclic acid. Only para-aminosalicylic acid showed consistent activity against Mycobacterium tuberculosis. These data suggest that the principle of activity of sulfasalazine in Crohn's disease is not an antimycobacterial effect. |
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Authors:
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D Van Caekenberghe |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of laboratory and clinical medicine Volume: 114 ISSN: 0022-2143 ISO Abbreviation: J. Lab. Clin. Med. Publication Date: 1989 Jul |
Date Detail:
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Created Date: 1989-08-01 Completed Date: 1989-08-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375375 Medline TA: J Lab Clin Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 63-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Medical Microbiology, Military Hospital, Brussels, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Crohn Disease
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drug therapy,
microbiology* Humans Microbial Sensitivity Tests Mycobacterium / drug effects* Mycobacterium tuberculosis / drug effects Structure-Activity Relationship Sulfasalazine / pharmacology* Sulfonamides / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Sulfonamides; 599-79-1/Sulfasalazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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