Document Detail

Crohn's disease, sulfasalazine, and mycobacteria.
MedLine Citation:
PMID:  2567777     Owner:  NLM     Status:  MEDLINE    
The in vitro antimycobacterial activities of sulfasalazine and its split products, mesalazine (5-aminosalicylic acid) and sulfapyridine, against 170 mycobacterial strains belonging to 17 species were compared with those of diaminodiphenylsulfone, sulfadimethoxine, olsalazine, and para-aminosalicyclic acid. Only para-aminosalicylic acid showed consistent activity against Mycobacterium tuberculosis. These data suggest that the principle of activity of sulfasalazine in Crohn's disease is not an antimycobacterial effect.
D Van Caekenberghe
Related Documents :
4877737 - Experience with three brescia-cimino shunts.
14256807 - Cobalt compounds as antidotes for hydrocyanic acid.
22536487 - (+)-z-bisdehydrodoisynolic acid enhances basal metabolism and fatty acid oxidation in f...
24600857 - Utilization of rapeseed pellet from fatty acid methyl esters production as an energy so...
16658657 - Ethylene-induced tropism of trifolium fragiferum l. stolons.
23970347 - Predominant role of vasoconstrictors over dilatators derived from arachidonic acid in h...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of laboratory and clinical medicine     Volume:  114     ISSN:  0022-2143     ISO Abbreviation:  J. Lab. Clin. Med.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-08-01     Completed Date:  1989-08-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375375     Medline TA:  J Lab Clin Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  63-5     Citation Subset:  AIM; IM    
Department of Medical Microbiology, Military Hospital, Brussels, Belgium.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Crohn Disease / drug therapy,  microbiology*
Microbial Sensitivity Tests
Mycobacterium / drug effects*
Mycobacterium tuberculosis / drug effects
Structure-Activity Relationship
Sulfasalazine / pharmacology*
Sulfonamides / pharmacology*
Reg. No./Substance:
0/Sulfonamides; 599-79-1/Sulfasalazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Crypticola clavulifera gen. et sp. nov. and Lagenidium giganteum: oomycetes pathogenic for dipterans...
Next Document:  Intracerebral drug delivery in rats with lesion-induced memory deficits.