Document Detail


Crohn's disease, sulfasalazine, and mycobacteria.
MedLine Citation:
PMID:  2567777     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The in vitro antimycobacterial activities of sulfasalazine and its split products, mesalazine (5-aminosalicylic acid) and sulfapyridine, against 170 mycobacterial strains belonging to 17 species were compared with those of diaminodiphenylsulfone, sulfadimethoxine, olsalazine, and para-aminosalicyclic acid. Only para-aminosalicylic acid showed consistent activity against Mycobacterium tuberculosis. These data suggest that the principle of activity of sulfasalazine in Crohn's disease is not an antimycobacterial effect.
Authors:
D Van Caekenberghe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of laboratory and clinical medicine     Volume:  114     ISSN:  0022-2143     ISO Abbreviation:  J. Lab. Clin. Med.     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-08-01     Completed Date:  1989-08-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375375     Medline TA:  J Lab Clin Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  63-5     Citation Subset:  AIM; IM    
Affiliation:
Department of Medical Microbiology, Military Hospital, Brussels, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Crohn Disease / drug therapy,  microbiology*
Humans
Microbial Sensitivity Tests
Mycobacterium / drug effects*
Mycobacterium tuberculosis / drug effects
Structure-Activity Relationship
Sulfasalazine / pharmacology*
Sulfonamides / pharmacology*
Chemical
Reg. No./Substance:
0/Sulfonamides; 599-79-1/Sulfasalazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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