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Crohn's disease revealed by a cheilitis granulomatosa with favorable evolution by perfusions of infliximab: Report of a case and review of the literature.
MedLine Citation:
PMID:  21251899     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Orofacial granulomatosis has been suggested as a generic term encompassing the inflammatory manifestations of several different diseases including Crohn's disease (CD). Moreover, oral lesions are considered to be an important extra-intestinal manifestation of CD. Granulomatous cheilitis (GC) is characterized by recurrent swelling of the labial tissues, a granulomatous histology and has been recognized to be a possible extra-intestinal manifestation of CD and may follow, coincide with or precede the onset of inflammatory digestive disease. We report the case of an 18-year-old woman with CD preceded 3 years ago by a GC. The patient was successfully treated with anti-TNFα on symptoms of CD and GC. The orofacial and digestive lesions were initially controlled with perfusions of infliximab, however, an isolated recurrence of the orofacial lesions requires an increase in the perfusion rate from every 6 to every 8 weeks to maintain a complete and persistent remission of the cheilitis granulomatosa.
Authors:
Gilles Macaigne; Florence Harnois; Jean-François Boivin; Dorian Dikov; Gilles Ridoux; Sadek Cheaib; Claude Chayette
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-18
Journal Detail:
Title:  Gastroenterologie clinique et biologique     Volume:  -     ISSN:  2210-7401     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704825     Medline TA:  Gastroenterol Clin Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010 Elsevier Masson SAS. All rights reserved.
Affiliation:
Department of Hepato-Gastroenterology, Lagny-Marne-la-Vallée Hospital, 34, avenue du Général-Leclerc, 77405 Lagny-sur-Marne cedex, France.
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