Document Detail

Crohn's disease and pregnancy.
MedLine Citation:
PMID:  2209277     Owner:  NLM     Status:  MEDLINE    
Seventy-eight pregnancies in 50 patients were reviewed to evaluate the effects of Crohn's disease on the outcome of pregnancy and the influence of the pregnancy on the course of Crohn's disease. Overall, 21 pregnancies (27 percent) had abnormal outcomes including spontaneous abortions (9), infants small for gestational age (6), premature infants (5), and infants who developed respiratory distress (1). Eight (50 percent) patients with active disease compared with 13 (21 percent) patients with inactive disease at conception had abnormal outcomes (P less than 0.05). During pregnancy 15 (55 percent) with active disease and 6 (12 percent) with inactive disease had an abnormal outcome (P less than 0.001). Neither medical nor surgical treatment, independent of disease activity, appeared to affect the outcome adversely. Eighteen of 73 (25 percent) patients with quiescent or mild disease relapsed, and seven of 16 patients with some disease activity improved (44 percent). Of 34 patients on medication, nine relapsed (27 percent), and of 39 patients not on medication, nine relapsed (24 percent) (P = N.S.). These results suggest that the outcome of pregnancy is not adversely affected by Crohn's disease. However, patients with active disease at conception and/or during the pregnancy have poorer outcomes independent of the use of medication or requirement of surgery. Neither pregnancy nor medications taken affect the course of the disease.
K Woolfson; Z Cohen; R S McLeod
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diseases of the colon and rectum     Volume:  33     ISSN:  0012-3706     ISO Abbreviation:  Dis. Colon Rectum     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1990-11-19     Completed Date:  1990-11-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372764     Medline TA:  Dis Colon Rectum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  869-73     Citation Subset:  IM    
Division of General Surgery, Toronto General Hospital, Canada.
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MeSH Terms
Crohn Disease* / drug therapy,  physiopathology,  surgery
Pregnancy Complications* / drug therapy,  physiopathology,  surgery
Pregnancy Outcome*
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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