| Critical test evaluation (1977-1992) of drug efficacy against endoparasites featuring benzimidazole-resistant small strongyles (population S) in Shetland ponies. | |
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MedLine Citation:
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PMID: 8988557 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several compounds (n = 13 single or combinations; most at therapeutic dosages) were evaluated between 1977 and 1992 in critical tests (n = 91) against benzimidazole (BZ) resistant small strongyles (Population S) and several other species of internal parasites in Shetland ponies, mostly under 1 year old. The closed breeding herd, from which the test ponies were selected, had been treated every 8 weeks with cambendazole (CBZ) for 4 years (1974-1978) and oxibendazole (OBZ) for 14 years (1978-1992). Published field test data (1974-1992) on older ponies in the herd showed BZ resistance of small strongyles. Average efficacies in the present critical tests against small strongyles for OBZ (n = 59 animals) were high in early years (95% or higher), but gradually declined to a low of 1% in 1991. Side-resistance of small strongyles was evident in critical tests (n = 1-6/single drug or combination) for several other BZs and a pro-BZ; ivermectin and piperazine were highly active, but pyrantel pamoate exhibited weak activity. BZ resistance was evident for six small strongyle species (Cyathostomum catinatum, Cyathostomum coronatum, Cylicocylus nassatus, Cylicostephanus calicatus, Cylicostephanus goldi, and Cylicostephanus longibursatus). Activity on bots, ascarids, large strongyles, and pinworms was essentially as expected, indicating no drug resistance. |
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Authors:
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E T Lyons; S C Tolliver; J H Drudge; S Stamper; T W Swerczek; D E Granstrom |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Veterinary parasitology Volume: 66 ISSN: 0304-4017 ISO Abbreviation: Vet. Parasitol. Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1997-09-18 Completed Date: 1997-09-18 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7602745 Medline TA: Vet Parasitol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 67-73 Citation Subset: IM |
Affiliation:
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Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington 40546-0099, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anthelmintics / pharmacology*, therapeutic use Benzimidazoles / pharmacology*, therapeutic use Drug Resistance Feces / parasitology Female Horses Intestinal Diseases, Parasitic / drug therapy, parasitology, veterinary* Male Parasite Egg Count / veterinary Strongyle Infections, Equine / drug therapy*, parasitology Strongyloidea / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Anthelmintics; 0/Benzimidazoles |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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