Document Detail

Critical test evaluation (1977-1992) of drug efficacy against endoparasites featuring benzimidazole-resistant small strongyles (population S) in Shetland ponies.
MedLine Citation:
PMID:  8988557     Owner:  NLM     Status:  MEDLINE    
Several compounds (n = 13 single or combinations; most at therapeutic dosages) were evaluated between 1977 and 1992 in critical tests (n = 91) against benzimidazole (BZ) resistant small strongyles (Population S) and several other species of internal parasites in Shetland ponies, mostly under 1 year old. The closed breeding herd, from which the test ponies were selected, had been treated every 8 weeks with cambendazole (CBZ) for 4 years (1974-1978) and oxibendazole (OBZ) for 14 years (1978-1992). Published field test data (1974-1992) on older ponies in the herd showed BZ resistance of small strongyles. Average efficacies in the present critical tests against small strongyles for OBZ (n = 59 animals) were high in early years (95% or higher), but gradually declined to a low of 1% in 1991. Side-resistance of small strongyles was evident in critical tests (n = 1-6/single drug or combination) for several other BZs and a pro-BZ; ivermectin and piperazine were highly active, but pyrantel pamoate exhibited weak activity. BZ resistance was evident for six small strongyle species (Cyathostomum catinatum, Cyathostomum coronatum, Cylicocylus nassatus, Cylicostephanus calicatus, Cylicostephanus goldi, and Cylicostephanus longibursatus). Activity on bots, ascarids, large strongyles, and pinworms was essentially as expected, indicating no drug resistance.
E T Lyons; S C Tolliver; J H Drudge; S Stamper; T W Swerczek; D E Granstrom
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Veterinary parasitology     Volume:  66     ISSN:  0304-4017     ISO Abbreviation:  Vet. Parasitol.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-09-18     Completed Date:  1997-09-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7602745     Medline TA:  Vet Parasitol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  67-73     Citation Subset:  IM    
Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington 40546-0099, USA.
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MeSH Terms
Anthelmintics / pharmacology*,  therapeutic use
Benzimidazoles / pharmacology*,  therapeutic use
Drug Resistance
Feces / parasitology
Intestinal Diseases, Parasitic / drug therapy,  parasitology,  veterinary*
Parasite Egg Count / veterinary
Strongyle Infections, Equine / drug therapy*,  parasitology
Strongyloidea / drug effects*
Reg. No./Substance:
0/Anthelmintics; 0/Benzimidazoles

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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