| Critical periods of susceptibility to short-term energy challenge during pregnancy: Impact on fertility and offspring development. | |
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MedLine Citation:
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PMID: 19891981 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In female mammals, reproduction is tightly regulated by energy status and food availability. Although acute energetic challenges inhibit female reproductive behavior and gonadotropin secretion, less attention has been given to the effects of short-term energetic challenge on pregnancy and gestation. Furthermore, species differences in pregnancy physiology necessitate more detailed analyses of specific pregnancy models. Here, we studied musk shrews, which display induced ovulation and obligate delayed implantation, and whose reproductive physiology is tightly linked to metabolic status. We tested whether acute energetic challenges of varied degrees given at specific pregnancy stages (including before and after delayed implantation) have different effects on gestational outcome and offspring postnatal development. We found that 48 h of either 40% or 50% food restriction, which reduced body weight and strongly inhibited sexual behavior, had minimal effects on pregnancy success and litter dynamics when administered early in gestation (pre-implantation). However, <30% of females experiencing short-term food restriction later in gestation successfully gave birth (versus > or =70% of ad-libitum fed controls), and the pups of these food-restricted females exhibited a 30% slower postnatal growth trajectory. Interestingly, although pregnancy success and litter dynamics were unaffected by food restriction before implantation, gestation length was increased by metabolic challenges experienced at this time, indicating that energy status may regulate the timing of implantation. We conclude that 1) there are critical periods of pregnancy, particularly after implantation, when short-term, mild energetic challenges have significant impacts on fertility and offspring postnatal development, and 2) delayed implantation may have evolved, in part, as a buffering mechanism to prevent pregnancy failure during impaired energy balance in early gestation. |
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Authors:
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Alexander S Kauffman; Karolina Bojkowska; Emilie F Rissman |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Physiology & behavior Volume: 99 ISSN: 1873-507X ISO Abbreviation: Physiol. Behav. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-17 Completed Date: 2010-03-01 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: United States |
Other Details:
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Languages: eng Pagination: 100-8 Citation Subset: IM |
Affiliation:
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Dept. of Reproductive Medicine, University of California, San Diego, La Jolla, CA, 92093, United States. akauffman@ucsd.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Body Weight Disease Susceptibility* Eating / physiology Fasting / physiology Female Fertility / physiology* Fetal Development / physiology* Litter Size Male Nutritional Status Pregnancy / physiology* Pregnancy Outcome* Pregnancy, Animal* Sexual Behavior, Animal Shrews Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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F32 MH070084-02/MH/NIMH NIH HHS; R00 HD056157/HD/NICHD NIH HHS; R00 HD056157-03/HD/NICHD NIH HHS; R00 HD056157-05/HD/NICHD NIH HHS; R01 MH068729-01A1/MH/NIMH NIH HHS; R01 MH57759/MH/NIMH NIH HHS |
| Comments/Corrections | |
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