| Critical period programming of intestinal glucose transport via alterations in dietary fatty acid composition. | |
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MedLine Citation:
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PMID: 2187579 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intestinal adaptation occurs in response to physiological or pathological processes that include resection, aging, diabetes, radiation, lactation, chronic alcohol feeding, and feeding diets of varying lipid, protein, or carbohydrate composition. The mechanisms involved in the adaptive response include alterations in morphology, cell kinetics, digestive enzyme activity, transport, membrane lipid composition, and enzymes involved in lipid metabolism. This discussion will review the effect of aging and alterations in dietary fatty acid composition on the small intestine. In addition, it may be possible to program the intestinal response to aging by feeding diets of differing fatty acid composition during the critical period of weaning. Alterations in the ratio of polyunsaturated to saturated fatty acids in the diet modifies the age-associated changes in the intestinal uptake of glucose. The changes occur rapidly, progressively, and irreversibly, suggesting that the intestinal uptake of glucose is subject to critical period programming. The mechanism by which diet may modify the ability of the intestine to up- or down-regulate glucose transport requires further investigation. |
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Authors:
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M Keelan; A B Thomson; M L Garg; M T Clandinin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Canadian journal of physiology and pharmacology Volume: 68 ISSN: 0008-4212 ISO Abbreviation: Can. J. Physiol. Pharmacol. Publication Date: 1990 May |
Date Detail:
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Created Date: 1990-06-28 Completed Date: 1990-06-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372712 Medline TA: Can J Physiol Pharmacol Country: CANADA |
Other Details:
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Languages: eng Pagination: 642-5 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Alberta, Edmonton, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dietary Fats / pharmacology* Fatty Acids / pharmacology* Glucose / metabolism* Humans Intestinal Mucosa / metabolism*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Fatty Acids; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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