| Critical period for acoustic preference in mice. | |
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MedLine Citation:
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PMID: 23045690 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Preference behaviors are often established during early life, but the underlying neural circuit mechanisms remain unknown. Adapting a unique nesting behavior assay, we confirmed a "critical period" for developing music preference in C57BL/6 mice. Early music exposure between postnatal days 15 and 24 reversed their innate bias for silent shelter, which typically could not be altered in adulthood. Instead, exposing adult mice treated acutely with valproic acid or carrying a targeted deletion of the Nogo receptor (NgR(-/-)) unmasked a strong plasticity of preference consistent with a reopening of the critical period as seen in other systems. Imaging of cFos expression revealed a prominent neuronal activation in response to the exposed music in the prelimbic and infralimbic medial prefrontal cortex only under conditions of open plasticity. Neither behavioral changes nor selective medial prefrontal cortex activation was observed in response to pure tone exposure, indicating a music-specific effect. Open-field center crossings were increased concomitant with shifts in music preference, suggesting a potential anxiolytic effect. Thus, music may offer both a unique window into the emotional state of mice and a potentially efficient assay for molecular "brakes" on critical period plasticity common to sensory and higher order brain areas. |
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Authors:
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Eun-Jin Yang; Eric W Lin; Takao K Hensch |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-10-08 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 109 Suppl 2 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-17 Completed Date: 2013-01-16 Revised Date: 2013-04-15 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 17213-20 Citation Subset: IM |
Affiliation:
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Center for Brain Science, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Animals Anxiety / physiopathology, psychology Auditory Cortex / drug effects, growth & development*, physiology* Behavior, Animal / drug effects, physiology* Female GPI-Linked Proteins / deficiency, genetics, physiology Male Mice Mice, Inbred C57BL Mice, Knockout Music / psychology Myelin Proteins / deficiency, genetics, physiology Neuronal Plasticity / physiology Receptors, Cell Surface / deficiency, genetics, physiology Valproic Acid / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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1P50MH094271/MH/NIMH NIH HHS; //Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/GPI-Linked Proteins; 0/Myelin Proteins; 0/Receptors, Cell Surface; 0/Rtn4r protein, mouse; 99-66-1/Valproic Acid |
| Comments/Corrections | |
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