Document Detail

Critical period for acoustic preference in mice.
MedLine Citation:
PMID:  23045690     Owner:  NLM     Status:  MEDLINE    
Preference behaviors are often established during early life, but the underlying neural circuit mechanisms remain unknown. Adapting a unique nesting behavior assay, we confirmed a "critical period" for developing music preference in C57BL/6 mice. Early music exposure between postnatal days 15 and 24 reversed their innate bias for silent shelter, which typically could not be altered in adulthood. Instead, exposing adult mice treated acutely with valproic acid or carrying a targeted deletion of the Nogo receptor (NgR(-/-)) unmasked a strong plasticity of preference consistent with a reopening of the critical period as seen in other systems. Imaging of cFos expression revealed a prominent neuronal activation in response to the exposed music in the prelimbic and infralimbic medial prefrontal cortex only under conditions of open plasticity. Neither behavioral changes nor selective medial prefrontal cortex activation was observed in response to pure tone exposure, indicating a music-specific effect. Open-field center crossings were increased concomitant with shifts in music preference, suggesting a potential anxiolytic effect. Thus, music may offer both a unique window into the emotional state of mice and a potentially efficient assay for molecular "brakes" on critical period plasticity common to sensory and higher order brain areas.
Eun-Jin Yang; Eric W Lin; Takao K Hensch
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-10-08
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  109 Suppl 2     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-17     Completed Date:  2013-01-16     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  17213-20     Citation Subset:  IM    
Center for Brain Science, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
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MeSH Terms
Acoustic Stimulation
Anxiety / physiopathology,  psychology
Auditory Cortex / drug effects,  growth & development*,  physiology*
Behavior, Animal / drug effects,  physiology*
GPI-Linked Proteins / deficiency,  genetics,  physiology
Mice, Inbred C57BL
Mice, Knockout
Music / psychology
Myelin Proteins / deficiency,  genetics,  physiology
Neuronal Plasticity / physiology
Receptors, Cell Surface / deficiency,  genetics,  physiology
Valproic Acid / pharmacology
Grant Support
1P50MH094271/MH/NIMH NIH HHS; //Canadian Institutes of Health Research
Reg. No./Substance:
0/GPI-Linked Proteins; 0/Myelin Proteins; 0/Receptors, Cell Surface; 0/Rtn4r protein, mouse; 99-66-1/Valproic Acid

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