| Critical function of death-associated protein 3 in T cell receptor-mediated apoptosis induction. | |
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MedLine Citation:
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PMID: 20381457 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Death-associated protein 3 (DAP3) is crucial for promoting apoptosis induced by various stimulations. This report demonstrates that DAP3 is also important for T cell receptor (TCR)-mediated apoptosis induction in immature thymocytes. Enforced expression of DAP3 accelerated the negative selection in developing thymocytes, using the reaggregate thymus organ culture system. In addition, expression of DAP3 accelerated TCR-mediated apoptosis induction in DO11.10 cells. We also demonstrated that DAP3 translocates into the nucleus during TCR-mediated apoptosis in a Nur77 dependent manner. It is concluded that DAP3 is critical for TCR-mediated induction of apoptosis at the downstream of Nur77. |
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Authors:
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Noriko Tosa; Atsushi Iwai; Taku Tanaka; Tomoka Kumagai; Takeshi Nitta; Satoko Chiba; Masahiro Maeda; Yousuke Takahama; Toshimitsu Uede; Tadaaki Miyazaki |
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Publication Detail:
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Type: Journal Article Date: 2010-04-08 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 395 ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-10 Completed Date: 2010-06-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 356-60 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Institute for Animal Experimentation, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-8638, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Active Transport, Cell Nucleus Animals Apoptosis* Cell Nucleus / metabolism Mice Nuclear Receptor Subfamily 4, Group A, Member 1 / physiology Proteins / genetics, metabolism, physiology* Receptors, Antigen, T-Cell / agonists, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Dap3 protein, mouse; 0/Nr4a1 protein, mouse; 0/Nuclear Receptor Subfamily 4, Group A, Member 1; 0/Proteins; 0/Receptors, Antigen, T-Cell |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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