| Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin. | |
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MedLine Citation:
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PMID: 18724372 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inflammasomes are cytosolic multiprotein complexes that sense microbial infection and trigger cytokine production and cell death. However, the molecular components of inflammasomes and what they sense remain poorly defined. Here we demonstrate that 35 amino acids of the carboxyl terminus of flagellin triggered inflammasome activation in the absence of bacterial contaminants or secretion systems. To further elucidate the host flagellin-sensing pathway, we generated mice deficient in the intracellular sensor Naip5. These mice failed to activate the inflammasome in response to the 35 amino acids of flagellin or in response to Legionella pneumophila infection. Our data clarify the molecular basis for the cytosolic response to flagellin. |
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Authors:
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Karla L Lightfield; Jenny Persson; Sky W Brubaker; Chelsea E Witte; Jakob von Moltke; Eric A Dunipace; Thomas Henry; Yao-Hui Sun; Dragana Cado; William F Dietrich; Denise M Monack; Renée M Tsolis; Russell E Vance |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-08-24 |
Journal Detail:
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Title: Nature immunology Volume: 9 ISSN: 1529-2916 ISO Abbreviation: Nat. Immunol. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-18 Completed Date: 2008-10-14 Revised Date: 2013-06-05 |
Medline Journal Info:
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Nlm Unique ID: 100941354 Medline TA: Nat Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 1171-8 Citation Subset: IM |
Affiliation:
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School of Public Health, University of California, Berkeley, CA 94720, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Motifs
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immunology Animals Apoptosis Regulatory Proteins / immunology, metabolism Calcium-Binding Proteins / immunology, metabolism Cytosol Enzyme-Linked Immunosorbent Assay Flagellin / chemistry, immunology* Immunoblotting Legionella pneumophila / immunology Legionnaires' Disease / immunology Macrophages / immunology*, microbiology Mice Multiprotein Complexes / immunology* Neuronal Apoptosis-Inhibitory Protein / genetics, immunology* Toll-Like Receptor 5 / immunology, metabolism Transduction, Genetic |
| Grant Support | |
ID/Acronym/Agency:
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AI070739/AI/NIAID NIH HHS; AI075039/AI/NIAID NIH HHS; K22 AI070739-02/AI/NIAID NIH HHS; R01 AI075039/AI/NIAID NIH HHS; R01 AI075039-01A2/AI/NIAID NIH HHS; R01 AI075039-04/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apoptosis Regulatory Proteins; 0/Birc1e protein, mouse; 0/Calcium-Binding Proteins; 0/Ipaf protein, mouse; 0/Multiprotein Complexes; 0/Neuronal Apoptosis-Inhibitory Protein; 0/Toll-Like Receptor 5; 12777-81-0/Flagellin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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