Document Detail

Critical developmental periods in the pathogenesis of hypertension.
MedLine Citation:
PMID:  22827878     Owner:  NLM     Status:  In-Data-Review    
Hypertension is one of the major risk factor of cardiovascular diseases, but after a century of clinical and basic research, the discrete etiology of this disease is still not fully understood. One reason is that blood pressure is a quantitative trait with multifactorial determination. Numerous genes, environmental factors as well as epigenetic factors should be considered. There is no doubt that although the full manifestation of hypertension and other cardiovascular diseases usually occurs predominantly in adulthood and/or senescence, the roots can be traced back to early ontogeny. The detailed knowledge of the ontogenetic changes occurring in the cardiovascular system of experimental animals during particular critical periods (developmental windows) could help to solve this problem in humans and might facilitate the age-specific prevention of human hypertension. We thus believe that this approach might contribute to the reduction of cardiovascular morbidity among susceptible individuals in the future.
J Kuneš; M Kadlecová; I Vaněčková; J Zicha
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiological research / Academia Scientiarum Bohemoslovaca     Volume:  61 Suppl 1     ISSN:  1802-9973     ISO Abbreviation:  Physiol Res     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112413     Medline TA:  Physiol Res     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  S9-S17     Citation Subset:  IM    
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.
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