Document Detail

Critical analysis of engineering aspects of shaken flask bioreactors.
MedLine Citation:
PMID:  19929318     Owner:  NLM     Status:  MEDLINE    
Shaking bioreactors are the most frequently used reaction vessels in biotechnology. Since their inception, shaking bioreactors have been playing a significant role in medicine, agriculture, food, environmental, and industrial research. In spite of their huge practical importance, very little is known about the characteristic properties of shaken cultures from an engineering point of view. In this paper, a critical analysis is presented of the mixing characteristics, aeration, mass and heat transfer, power consumption, and suitability for on-line monitoring and control of various environmental and other operating parameters in aerated and anaerobic/anoxic conditions. Aspects of cell damage due to shear stress generated in shaken flask and loss of sterility due to contamination are also discussed.
S Suresh; V C Srivastava; I M Mishra
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Critical reviews in biotechnology     Volume:  29     ISSN:  1549-7801     ISO Abbreviation:  Crit. Rev. Biotechnol.     Publication Date:  2009  
Date Detail:
Created Date:  2009-11-25     Completed Date:  2010-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8505177     Medline TA:  Crit Rev Biotechnol     Country:  England    
Other Details:
Languages:  eng     Pagination:  255-78     Citation Subset:  IM    
Department of Chemical Engineering, Indian Institute of Technology Roorkee, Uttarakhand, India.
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MeSH Terms
Bioengineering / methods*
Culture Techniques / methods*
Stress, Physiological

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