Document Detail


Critical windows of fetal lead exposure: adverse impacts on length of gestation and risk of premature delivery.
MedLine Citation:
PMID:  21063188     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Research on the role of environmental lead exposure in the complex etiology of premature birth has yielded inconsistent results. We assessed the trimester-specific effect of prenatal lead exposure on gestational age and risk of premature delivery.
METHODS: We used linear and logistic regression to identify critical windows of susceptibility to lead exposure on gestational length.
RESULTS: In single-trimester models, decreases in gestational length were most strongly associated with first and second trimester blood lead. In adjusted logistic regression models, a one-standard deviation increase in second trimester blood lead was associated with an odds ratio of prematurity of 1.75 (95% CI: 1.02, 3.02).
CONCLUSIONS: Maternal whole blood lead levels measured during first and second trimesters yielded the most prominent inverse association with length of gestation and increased the risk of prematurity.
Authors:
David Cantonwine; Howard Hu; Brisa N Sánchez; Héctor Lamadrid-Figueroa; Donald Smith; Adrienne S Ettinger; Adriana Mercado-García; Mauricio Hernández-Avila; Robert O Wright; Martha Maria Téllez-Rojo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine     Volume:  52     ISSN:  1536-5948     ISO Abbreviation:  J. Occup. Environ. Med.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-10     Completed Date:  2011-05-23     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  9504688     Medline TA:  J Occup Environ Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1106-11     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood
Cohort Studies
Female
Gestational Age*
Humans
Lead / adverse effects*,  blood
Logistic Models
Maternal Exposure / adverse effects*
Mexico / epidemiology
Pregnancy
Pregnancy Outcome
Pregnancy Trimesters
Premature Birth / chemically induced*,  epidemiology*
Risk Factors
Young Adult
Grant Support
ID/Acronym/Agency:
K23 ES000381/ES/NIEHS NIH HHS; K23ES000381/ES/NIEHS NIH HHS; P01 ES012874/ES/NIEHS NIH HHS; P30 ES000002/ES/NIEHS NIH HHS; P42 ES05947/ES/NIEHS NIH HHS; R01 ES007821/ES/NIEHS NIH HHS; R01 ES007821-11/ES/NIEHS NIH HHS; R01 ES013744/ES/NIEHS NIH HHS; R01 ES013744/ES/NIEHS NIH HHS; R01 ES013744-05/ES/NIEHS NIH HHS; R01 ES014930/ES/NIEHS NIH HHS; R01 ES014930/ES/NIEHS NIH HHS; R01 ES014930-05/ES/NIEHS NIH HHS; R01-ES007821/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 2P299V784P/Lead
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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