Document Detail


Critical variables associated with nonbiodegradable osmotically controlled implants.
MedLine Citation:
PMID:  20490735     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Osmotically controlled implants yield precise zero-order drug delivery kinetics and are utilized in a number of applications. The implants deliver drugs for extended periods (weeks to years) and exhibit good in vivo/in vitro correlation. This paper reviews critical variables associated with these implants, with a focus on release rate testing. The extended-duration kinetics can be problematic when attempting to test for >70% cumulative delivery. An innovative scheme based on the scientific principles of operation of the system is described to ensure > 70% delivery at the target rate and duration for the DUROS Viadur (leuprolide acetate) implant.
Authors:
Jeremy C Wright
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-05-19
Journal Detail:
Title:  The AAPS journal     Volume:  12     ISSN:  1550-7416     ISO Abbreviation:  AAPS J     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-06-22     Completed Date:  2010-10-21     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101223209     Medline TA:  AAPS J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  437-42     Citation Subset:  IM    
Affiliation:
DURECT Corporation, 2 Results Way, Cupertino, California 95014, USA. jeremy.wright@durect.com
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MeSH Terms
Descriptor/Qualifier:
Drug Implants*
Osmosis
Pharmacokinetics
Chemical
Reg. No./Substance:
0/Drug Implants
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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