Document Detail

A critical review of vitamin C for the prevention of age-related cognitive decline and Alzheimer's disease.
MedLine Citation:
PMID:  22366772     Owner:  NLM     Status:  MEDLINE    
Antioxidants in the diet have long been thought to confer some level of protection against the oxidative damage that is involved in the pathology of Alzheimer's disease as well as general cognitive decline in normal aging. Nevertheless, support for this hypothesis in the literature is equivocal. In the case of vitamin C (ascorbic acid) in particular, lack of consideration of some of the specific features of vitamin C metabolism has led to studies in which classification of participants according to vitamin C status is inaccurate, and the absence of critical information precludes the drawing of appropriate conclusions. Vitamin C levels in plasma are not always reported, and estimated daily intake from food diaries may not be accurate or reflect actual plasma values. The ability to transport ingested vitamin C from the intestines into blood is limited by the saturable sodium-dependent vitamin C transporter (SVCT1) and thus very high intakes and the use of supplements are often erroneously considered to be of greater benefit that they really are. The current review documents differences among the studies in terms of vitamin C status of participants. Overall, there is a large body of evidence that maintaining healthy vitamin C levels can have a protective function against age-related cognitive decline and Alzheimer's disease, but avoiding vitamin C deficiency is likely to be more beneficial than taking supplements on top of a normal, healthy diet.
Fiona E Harrison
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Journal of Alzheimer's disease : JAD     Volume:  29     ISSN:  1875-8908     ISO Abbreviation:  J. Alzheimers Dis.     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-17     Completed Date:  2012-08-17     Revised Date:  2013-08-14    
Medline Journal Info:
Nlm Unique ID:  9814863     Medline TA:  J Alzheimers Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  711-26     Citation Subset:  IM    
Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
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MeSH Terms
Alzheimer Disease / blood,  prevention & control*
Antioxidants / administration & dosage*,  metabolism
Ascorbic Acid / administration & dosage*,  blood
Cognition Disorders / blood,  prevention & control*
Dietary Supplements
Sodium-Coupled Vitamin C Transporters / metabolism
Grant Support
1 R01AG038739-01/AG/NIA NIH HHS; R01 AG038739/AG/NIA NIH HHS
Reg. No./Substance:
0/Antioxidants; 0/Sodium-Coupled Vitamin C Transporters; 50-81-7/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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